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Budesonide Suppositories Are Effective and Safe for Treating Acute Ulcerative Proctitis  Wolfgang Kruis, Viacheslav Neshta, Marina Pesegova, Olga Alekseeva,

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Presentation on theme: "Budesonide Suppositories Are Effective and Safe for Treating Acute Ulcerative Proctitis  Wolfgang Kruis, Viacheslav Neshta, Marina Pesegova, Olga Alekseeva,"— Presentation transcript:

1 Budesonide Suppositories Are Effective and Safe for Treating Acute Ulcerative Proctitis 
Wolfgang Kruis, Viacheslav Neshta, Marina Pesegova, Olga Alekseeva, Pavel Andreev, Oleksii Datsenko, Olena Levchenko, Sayar Abdulkhakov, Yuriy Lozynskyy, Yuriy Mostovoy, Konstantin Soloviev, Andrey E. Dorofeyev, Michael Vieth, Michael Stiess, Roland Greinwald, Ralf Mohrbacher, Britta Siegmund  Clinical Gastroenterology and Hepatology  Volume 17, Issue 1, Pages e4 (January 2019) DOI: /j.cgh Copyright © 2019 AGA Institute Terms and Conditions

2 Figure 1 Patient disposition: intention-to-treat (ITT) and PP populations. Clinical Gastroenterology and Hepatology  , e4DOI: ( /j.cgh ) Copyright © 2019 AGA Institute Terms and Conditions

3 Figure 2 (A) Mean time to resolution of clinical symptoms defined as the first of 3 consecutive days with a score of 0 for rectal bleeding and stool frequency after 8-week treatment at the final/withdrawal visit (intention-to-treat [ITT] and PP population). P values for pairwise comparisons result from Cox proportional hazards regression model. (B) Time to resolution of clinical symptoms (ITT population) (Kaplan–Meier curves). Circles represent censoring of patients who discontinued the study or completed their final study visit without resolution. Clinical Gastroenterology and Hepatology  , e4DOI: ( /j.cgh ) Copyright © 2019 AGA Institute Terms and Conditions

4 Supplementary Figure 1 Secondary end points (intention-to-treat population). Percentages of patients with deep remission, clinical remission, endoscopic remission, and mucosal healing. P values indicate significance of pairwise comparisons according to the 95% CIs. All other comparisons showed no statistical significant difference. Clinical Gastroenterology and Hepatology  , e4DOI: ( /j.cgh ) Copyright © 2019 AGA Institute Terms and Conditions


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