1. The α2-adrenergic receptor antagonist yohimbine improves endotoxin-induced inhibition of gastrointestinal motility in mice 
N. Hamano, T. Inada, R. Iwata, T. Asai, K. Shingu 
British Journal of Anaesthesia 
Volume 98, Issue 4, Pages (April 2007)
DOI: /bja/aem011
Copyright © 2007 British Journal of Anaesthesia Terms and Conditions

2. Fig 1
Three hypothetical examples of the distribution of marker in the 10 segments of the small intestine. The distribution is expressed as GC (the centre of gravity) (= Σ(CiSi)/Σ(Ci), where Ci is the count in segment Si). (a) All the markers are in segment 1, therefore, the GC is 1 (1 × × 2 + · · · + 0 × 10 = 1). (b) All the markers are in segment 10, therefore, the GC is 10 (0 × 1 + · · · + 0 × × 10 = 10). (c) The markers are evenly distributed throughout the 10 segments, therefore, the GC is 5.5 [0.1 × ( · · · + 10) = 5.5].25
British Journal of Anaesthesia  , DOI: ( /bja/aem011)
Copyright © 2007 British Journal of Anaesthesia Terms and Conditions

3. Fig 2
Effect of yohimbine on lipopolysaccharide-induced inhibition of gastric emptying and gastrointestinal transit. Either yohimbine 25 µg or saline was injected s.c., 4 h before i.p. injection of lipopolysaccharide 100 µg or saline. Gastric emptying and gastrointestinal transit were measured 8 h after injection of lipopolysaccharide. Means and individual data are shown (n = 11–13). *P < 0.05 vs saline, #P < 0.05 vs lipopolysaccharide without yohimbine.
British Journal of Anaesthesia  , DOI: ( /bja/aem011)
Copyright © 2007 British Journal of Anaesthesia Terms and Conditions

4. Fig 3
Expression of iNOS in the gastrointestinal tract. Either yohimbine 25 µg or saline was injected s.c., 4 h before i.p. injection of lipopolysaccharide 100 µg or saline. Protein expression was determined 8 h after injection of lipopolysaccharide. (a) Representative data are shown. G, stomach; J, jejunum; I, ileum. Expression of actin was similar in all four groups, indicating an equal amount of protein was correctly applied. (b) iNOS expression (relative to actin expression) in the small intestine (the expression in the jejunum plus that in the ileum) is shown. (The expression in the stomach was not shown, as iNOS expression was not detected.) Medians and individual data from eight mice from each group are shown. *P < 0.05 vs saline, #P < 0.05 vs lipopolysaccharide without yohimbine.
British Journal of Anaesthesia  , DOI: ( /bja/aem011)
Copyright © 2007 British Journal of Anaesthesia Terms and Conditions

5. Fig 4
Effect of different doses of yohimbine on lipopolysaccharide-induced inhibition of gastric emptying and gastrointestinal transit. Yohimbine or saline was injected s.c. 4 h before i.p. injection of lipopolysaccharide 100 µg or saline. Gastric emptying and gastrointestinal transit were measured 8 h after injection of lipopolysaccharide. Medians, 95% confidence intervals of medians, and individual data are shown (n = 7). *P < vs saline. The dose of 8, 25, and 75 µg corresponds to ∼0.3, 1, and 3 mg kg− 1, respectively.
British Journal of Anaesthesia  , DOI: ( /bja/aem011)
Copyright © 2007 British Journal of Anaesthesia Terms and Conditions

6. Fig 5
Effect of yohimbine given after the onset of endotoxaemia on gastric emptying and gastrointestinal transit. Lipopolysaccharide 100 µg was injected i.p. Thirty minutes later, either yohimbine 25 µg or saline was injected i.p. Gastric emptying and gastrointestinal transit were measured 8 h after injection of lipopolysaccharide. Means and individual data are shown (n = 11). *P < 0.005, **P < vs saline.
British Journal of Anaesthesia  , DOI: ( /bja/aem011)
Copyright © 2007 British Journal of Anaesthesia Terms and Conditions