1. Carcinogenesis Bioassays
Dose-Response in Female Rats
100.0
90.0
80.0
70.0
liver tumors
60.0
Proportion Responding
50.0
pulmonary
tumors
40.0
• clear increase
• statistically significant increase
30.0
20.0
10.0
0.0 1 10
100
Dose

2. Carcinogenesis Bioassays
Dose-Response in Female Rats
100.0
mammary gland tumors
uterus tumors
90.0
80.0
70.0
60.0
Proportion Responding
50.0
40.0
• clear decrease
• statistically significant decrease
30.0
20.0
10.0
0.0 1 10
100
Dose

3. Carcinogenesis Bioassays
Dose-Response in Female Rats
300.0
250.0
200.0
150.0
• overall, not much change
• from first, and most influential bioassay of dioxin
• carcinogen in female rats?
total tumors
100.0
50.0
0.0 1 10
100
Dose