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Cotransplantation of Mesenchymal Stem Cells Might Prevent Death from Graft-versus- Host Disease (GVHD) without Abrogating Graft-versus-Tumor Effects after.

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Presentation on theme: "Cotransplantation of Mesenchymal Stem Cells Might Prevent Death from Graft-versus- Host Disease (GVHD) without Abrogating Graft-versus-Tumor Effects after."— Presentation transcript:

1 Cotransplantation of Mesenchymal Stem Cells Might Prevent Death from Graft-versus- Host Disease (GVHD) without Abrogating Graft-versus-Tumor Effects after HLA- Mismatched Allogeneic Transplantation following Nonmyeloablative Conditioning  Frédéric Baron, Chantal Lechanteur, Evelyne Willems, France Bruck, Etienne Baudoux, Laurence Seidel, Jean-François Vanbellinghen, Kaoutar Hafraoui, Marie Lejeune, André Gothot, Georges Fillet, Yves Beguin  Biology of Blood and Marrow Transplantation  Volume 16, Issue 6, Pages (June 2010) DOI: /j.bbmt Copyright © 2010 American Society for Blood and Marrow Transplantation Terms and Conditions

2 Figure 1 T cell engraftment kinetics (donor T cell chimerism levels) in MSC patients (white bars) and in historic patients (black bars). Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2010 American Society for Blood and Marrow Transplantation Terms and Conditions

3 Figure 2 (A) Cumulative incidence of grade II-IV aGVHD in study patients given MSC (MSC group, broken line) or in historic patients (solid line). (B) Cumulative incidence of moderate/severe cGVHD in study patients given MSC (MSC group, broken line) or in historic patients (solid line). Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2010 American Society for Blood and Marrow Transplantation Terms and Conditions

4 Figure 3 OS (A) and PFS (B) in study patients given MSC (MSC group, broken line) or in historic patients (solid line). Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2010 American Society for Blood and Marrow Transplantation Terms and Conditions


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