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Evidence for a true post-β-lactamase-inhibitor effect of clavulanic acid against Klebsiella pneumoniae and Haemophilus influenzae  V. Murbach, N. Dhoyen,

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Presentation on theme: "Evidence for a true post-β-lactamase-inhibitor effect of clavulanic acid against Klebsiella pneumoniae and Haemophilus influenzae  V. Murbach, N. Dhoyen,"— Presentation transcript:

1 Evidence for a true post-β-lactamase-inhibitor effect of clavulanic acid against Klebsiella pneumoniae and Haemophilus influenzae  V. Murbach, N. Dhoyen, L. Linger, H. Monteil, F. Jehl  Clinical Microbiology and Infection  Volume 7, Issue 12, Pages (December 2001) DOI: /j x Copyright © 2001 European Society of Clinical Infectious Diseases Terms and Conditions

2 Figure 1 General technical procedures investigating each of the effects studied: AMC, amoxicillin + clavulanic acid (2 mg/L); CA, clavulanic acid; AMX, amoxicillin; PAE, post-antibiotic effect; PLIE, post-β-lactamase-inhibitor effect; DG, delay in growth. Clinical Microbiology and Infection 2001 7, DOI: ( /j x) Copyright © 2001 European Society of Clinical Infectious Diseases Terms and Conditions

3 Figure 2 Evidence for PLIE after CA or AMX/CA exposure against H. influenzae: CA 1, clavulanic acid 1 mg/L; AMX 8, amoxicillin 8 mg/L; AMC 8/2, amoxicillin 8 mg/L + clavulanic acid 2 mg/L; PLIE, post-β-lactamase-inhibitor effect. Clinical Microbiology and Infection 2001 7, DOI: ( /j x) Copyright © 2001 European Society of Clinical Infectious Diseases Terms and Conditions


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