Presentation is loading. Please wait.

Presentation is loading. Please wait.

The effect of elevated homocysteine levels on adrenergic vasoconstriction of human resistance arteries: The role of the endothelium and reactive oxygen.

Published byMogens Bundgaard Modified over 5 years ago

Similar presentations

Presentation on theme: "The effect of elevated homocysteine levels on adrenergic vasoconstriction of human resistance arteries: The role of the endothelium and reactive oxygen."— Presentation transcript:

1 The effect of elevated homocysteine levels on adrenergic vasoconstriction of human resistance arteries: The role of the endothelium and reactive oxygen species  Marilyn J. Cipolla, PhD, W.Kent Williamson, MD, Mark L. Nehler, MD, Lloyd M. Taylor, MD, John M. Porter, MD  Journal of Vascular Surgery  Volume 31, Issue 4, Pages (April 2000) DOI: /mva Copyright © 2000 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

2 Fig. 1 Graph showing the concentration-response to norepinephrine (NE ) of arteries in PSS (control ; ●) and exposed to 200 μmol/L homocysteine (HC ; ○). *P <.05; **P <.01. Journal of Vascular Surgery  , DOI: ( /mva ) Copyright © 2000 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

3 Fig. 2 Graph showing the concentration-response to norepinephrine (NE ) of arteries exposed to 200 μmol/L homocysteine (HC ) in the absence (○) and presence (▵) of 1200 U/mL catalase and 120 U/mL SOD. Journal of Vascular Surgery  , DOI: ( /mva ) Copyright © 2000 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

4 Fig. 3 Graph showing the concentration-response to acetylcholine (ACh ) of arteries in PSS (control ; ●) and in 200 μmol/L homocysteine (HC ), (○). Journal of Vascular Surgery  , DOI: ( /mva ) Copyright © 2000 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

5 Fig. 4 Graph showing the concentration-response to SNP of arteries in PSS (control ; ●) and exposed to 200 μmol/L homocysteine (HC ; ○). Journal of Vascular Surgery  , DOI: ( /mva ) Copyright © 2000 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

6 Fig. 5 Diameter tracing of a denuded artery contracted with norepinephrine (NE ) and given a single concentration (150 μmol/L) of homocysteine (HC ), demonstrating the vasodilating effect of homocysteine. Journal of Vascular Surgery  , DOI: ( /mva ) Copyright © 2000 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

7 Fig. 6 Graph showing the concentration-response characteristics to homocysteine (HC ) of both intact (●) and denuded (○) arteries. Arteries were contracted with an intermediate concentration of norepinephrine (NE ), and homocysteine was added cumulatively to the arteriograph bath. *P <.05; **P <.01. Journal of Vascular Surgery  , DOI: ( /mva ) Copyright © 2000 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Download ppt "The effect of elevated homocysteine levels on adrenergic vasoconstriction of human resistance arteries: The role of the endothelium and reactive oxygen."

Similar presentations

Endothelial cell seeding reduces thrombogenicity of Dacron grafts in humans Per Örtenwall, MD, PhD *, Hans Wadenvik, MD, PhD **, Jack Kutti, MD, PhD **,

Endothelial cell seeding reduces thrombogenicity of Dacron grafts in humans Per Örtenwall, MD, PhD *, Hans Wadenvik, MD, PhD **, Jack Kutti, MD, PhD **,
The role of arteriovenous shunts in the pathogenesis of varicose veins Howard C. Baron, M.D., Sebastiano Cassaro, M.D. Journal of Vascular Surgery Volume.

The role of arteriovenous shunts in the pathogenesis of varicose veins Howard C. Baron, M.D., Sebastiano Cassaro, M.D. Journal of Vascular Surgery Volume.
The effect of inguinal lymphatic manipulation on regional lymph flow patterns Jeffrey R. Rubin, MD, Lisa B. Eberlin, MD Journal of Vascular Surgery Volume.

The effect of inguinal lymphatic manipulation on regional lymph flow patterns Jeffrey R. Rubin, MD, Lisa B. Eberlin, MD Journal of Vascular Surgery Volume.
A review of 100 consecutive reconstructions of the distal vertebral artery for embolic and hemodynamic disease  Ramon Berguer, MD, PhD, Mark D. Morasch,

A review of 100 consecutive reconstructions of the distal vertebral artery for embolic and hemodynamic disease  Ramon Berguer, MD, PhD, Mark D. Morasch,
Popliteal artery stenosis caused by a Baker's cyst

Popliteal artery stenosis caused by a Baker's cyst
Everett Y. Lam, MD, Robert B. McLafferty, MD, Lloyd M

Everett Y. Lam, MD, Robert B. McLafferty, MD, Lloyd M
Daniel J. Lindner, M. D. , James M. Edwards, M. D. , Edward S

Daniel J. Lindner, M. D. , James M. Edwards, M. D. , Edward S
Propionyl-L-carnitine dilates human subcutaneous arteries through an endothelium- dependent mechanism  Marilyn J. Cipolla, PhD, Alexander Nicoloff, MD,

Propionyl-L-carnitine dilates human subcutaneous arteries through an endothelium- dependent mechanism  Marilyn J. Cipolla, PhD, Alexander Nicoloff, MD,
Axillary-to-carotid artery bypass grafting for symptomatic severe common carotid artery occlusive disease  Joseph P. Archie, PhD, MD  Journal of Vascular.

Axillary-to-carotid artery bypass grafting for symptomatic severe common carotid artery occlusive disease  Joseph P. Archie, PhD, MD  Journal of Vascular.
Ultrasound measurement of the luminal diameter of the abdominal aorta and iliac arteries in patients without vascular disease  Ole Martin Pedersen, MD,

Ultrasound measurement of the luminal diameter of the abdominal aorta and iliac arteries in patients without vascular disease  Ole Martin Pedersen, MD,
Lloyd M. Taylor, M.D., Edward S. Phinney, M.D., John M. Porter, M.D. 

Lloyd M. Taylor, M.D., Edward S. Phinney, M.D., John M. Porter, M.D. 
Thermal laser-assisted balloon angioplasty of the superficial femoral artery: A multicenter review of 602 cases  David Rosenthal, MD, Felix A. Pesa, MD,

Thermal laser-assisted balloon angioplasty of the superficial femoral artery: A multicenter review of 602 cases  David Rosenthal, MD, Felix A. Pesa, MD,
Transmetatarsal amputation: The role of adjunctive revascularization

Transmetatarsal amputation: The role of adjunctive revascularization
Mycotic axillary artery aneurysm

Mycotic axillary artery aneurysm
Marilyn J. Cipolla, MS, Christian T. Harker, PhD, John M. Porter, MD 

Marilyn J. Cipolla, MS, Christian T. Harker, PhD, John M. Porter, MD 
A new valvulotome for in situ bypass grafts

A new valvulotome for in situ bypass grafts
Asymptomatic internal carotid artery aneurysm

Asymptomatic internal carotid artery aneurysm
Factors predicting the diameter of the popliteal artery in healthy humans  Thomas Sandgren, MD, Björn Sonesson, MD, PhD, Åsa Rydén Ahlgren, MD, Toste Länne,

Factors predicting the diameter of the popliteal artery in healthy humans  Thomas Sandgren, MD, Björn Sonesson, MD, PhD, Åsa Rydén Ahlgren, MD, Toste Länne,
Effects of exercise rehabilitation on cardiovascular risk factors in older patients with peripheral arterial occlusive disease  Anna Maria Izquierdo-Porrera,

Effects of exercise rehabilitation on cardiovascular risk factors in older patients with peripheral arterial occlusive disease  Anna Maria Izquierdo-Porrera,
Clinical outcome in patients with mild and moderate carotid artery stenosis  Brian F. Johnson, MD, Fabio Verlato, MD, Robert O. Bergelin, MS, Jean F. Primozich,

Clinical outcome in patients with mild and moderate carotid artery stenosis  Brian F. Johnson, MD, Fabio Verlato, MD, Robert O. Bergelin, MS, Jean F. Primozich,

Similar presentations

Ads by Google