1. Work Package 7 Sarah Edwards – Professor of Bioethics, UCL
Ben Quayle – consultant research assistant
10th January 2019

2. Work Package 7 Work Package Title:
“Engaging policy makers, global public health bodies and communities and ethical, administrative, regulatory and operational obstacles during outbreaks”
Lead by:
Prof. David Heymann - Royal Institute of International Affairs (Chatham House)
Co-Leads:
Dr. Osman Dar (Chatham House)
Prof. S. Edwards
Prof. A. Zumla (UCL)
Prof. Francine Ntoumi-Congo
Chatham House | The Royal Institute of International Affairs

3. WP7 – Overall Objectives
Using a One Health approach analyse the role of health system governance structures, and networks in addressing challenges to build laboratory, public health and clinical trial capacity for the rapid investigation of EID outbreaks with epidemic potential
To understand perceptions among key One Health stakeholders of EID risks and their level of support for specific interventions
To identify multi-sectoral strategies and institutional capacities for building appropriate levels of preparedness and response to EID outbreaks
To investigate the barriers that impede the rapid and effective responses to EID outbreaks and the uptake of capacity building mechanisms
Develop evidence-based, contextually-appropriate policy options
Set up ethical, regulatory and administrative systems ready to assess and approve rapid response protocols from the network within hours
Develop ethical and operational rules that regulators and ethics committees should use to inform the approval of a range of interventions from the network
To identify operational ‘pressure points’ and streamline administrative practices in gaining research authorisation, to create system that is both flexible and durable
Ensure regions have the capacity to respond efficiently to EID outbreaks
Chatham House | The Royal Institute of International Affairs

4. Deliverables Deliverable Number Deliverable Name
Lead Participant Organisation
Month deliverable will be achieved
7.1
Stakeholder analysis report
Chatham House Centre on Global Health Security
33.0
7.2
Roundtable event 1
9.0
7.3
Roundtable event 2
University College London (UCL)
21.0
7.4
Roundtable event 3
Fondation Congolaise pour la Recherche Médicale
36.0
7.5
Review of recommendation form Ebola Outbreak
University College London(UCL)
6.0
7.6
Workshops National
Institute for Medical
Research - Tanzania (NIMR)
24.0
7.7
Training programme
University of Zambia (UNZA)
7.8
Pool of ethical expertise among rapid response teams
7.9
New training material
7.10
Consensus statement (consensus amongst regulators and ethics committees harmonising ethical principles and regulatory rules)
30.0
7.11
Training programme (seminars for research regulators and ethics committees)
7.12
Appointment of an external ethics advisor
3.0
7.13
Ethics Monitoring by the external ethics advisor
Quarterly
Chatham House | The Royal Institute of International Affairs

5. Milestones Milestone Number Milestone Name Means of Verification
Month milestone will be attained
7.1
Roundtable 1
Published meeting summary
9.0
7.2
Roundtable 2
21.0
7.3
Roundtable 3
36.0
7.4
Stakeholder analysis study plan
Approved protocol by advisory group
6.0
7.5
Literature review and policy actor mapping
Peer-review  publication  and progress report on stakeholder analysis
18.0
7.6
In depth interviews and ranking exercise
Recorded and transcribed interviews and progress report
24.0
7.7
Analysis and final report write-up
Peer-reviewed publication
7.8
Review recommendations following Ebola
Report 6
7.9
Workshops
Attendance record and delegate feedback 24
7.10
Consensus statement
Analysis and published outcome 30
7.11
Training programme
7.12
Worked analysis of ethics and regulation 12
7.13
Pool of ethical expertise among rapid response teams
Portfolio of training records 36
7.14
Survey of operational systems completed
New training material produced
Traning material available publicly
7.15
Appointment of External independent Ethics Advisor
External independent Ethics Advisor appointed 03
Chatham House | The Royal Institute of International Affairs

6. Work Undertaken Recruitment
Consultant research assistant in place - Sept. 2018
Recruitment and initiation of Chatham House African Fellowship programme – July/Aug 2018
Organisation of launch/dissemination event – June 2018 – March 2019
To be held on the 15th MARCH 2019 at the African Union’s International Conference on (Re-)Emerging Infectious Diseases
Stakeholder mapping
performed for launch event
More systematic process underway presently – ToC adding to this
Review recommendations following Ebola
Initiated at this meeting – individual interviews and online survey will be used to collate information.
Chatham House | The Royal Institute of International Affairs

7. Future Work Chatham House African Fellowship Programme
Will recruit a fellow for the next three iterations of the programme
2018 cohort - Dr Raji Tajudeen (Africa CDC)
Media Training – with SciDev.net
Syllabus currently being finalised – will arrange first half of 2019
Complete Stakeholder Mapping
15th MARCH 2019 – Int. Conference on (Re-)Emerging Infectious Diseases
Chatham House | The Royal Institute of International Affairs

8. Prof. Zumla’s Requested Slide
WP collaborations
Working closely with WP 2 (WP5)
African Fellowship Programme
Covers new research & training
New Research Applications
Future work with
Project ECHO
WHO KOICA (training capacity for emergency response)
Involved with:
Africa CDC, Nigeria CDC, HORN, ILRI
Chatham House | The Royal Institute of International Affairs

9. Chatham House | The Royal Institute of International Affairs