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M. Bojan, S. Vicca, C. Boulat, S. Gioanni, P. Pouard 

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Presentation on theme: "M. Bojan, S. Vicca, C. Boulat, S. Gioanni, P. Pouard "— Presentation transcript:

1 Aprotinin, transfusions, and kidney injury in neonates and infants undergoing cardiac surgery 
M. Bojan, S. Vicca, C. Boulat, S. Gioanni, P. Pouard  British Journal of Anaesthesia  Volume 108, Issue 5, Pages (May 2012) DOI: /bja/aes002 Copyright © 2012 The Author(s) Terms and Conditions

2 Fig 1 Patient enrolment process over a 42 month period. Aprotinin was suspended from prophylactic use starting in the 20th month. Patients with missing data concerning transfusion and/or CPB characteristics and/or postoperative creatinine measurements were excluded. British Journal of Anaesthesia  , DOI: ( /bja/aes002) Copyright © 2012 The Author(s) Terms and Conditions

3 Fig 2 Number of blood product transfusions and CPB priming volumes across the study period. Data are shown as means and sd. There was a significant decrease in all blood product transfusions and in priming volumes over time, as shown by the results of analysis of variance, all P-values < Day 0: the day of surgery. British Journal of Anaesthesia  , DOI: ( /bja/aes002) Copyright © 2012 The Author(s) Terms and Conditions

4 Fig 3 Incidence of AKI and of AKI requiring PD across the study period. There was no linear trend for the overall AKI incidence, χ2 P-value=0.77, and the incidence of PD increased, χ2 P-value=0.02. British Journal of Anaesthesia  , DOI: ( /bja/aes002) Copyright © 2012 The Author(s) Terms and Conditions


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