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Asian Pacific Organization for Cancer Prevention (APOCP) Cancer Epidemiology and Prevention Education Screening Toxicological Pathology.

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Presentation on theme: "Asian Pacific Organization for Cancer Prevention (APOCP) Cancer Epidemiology and Prevention Education Screening Toxicological Pathology."— Presentation transcript:

1 Asian Pacific Organization for Cancer Prevention (APOCP) Cancer Epidemiology and Prevention Education Screening Toxicological Pathology

2 APOCP Groups Australasia Central Asia China Japan Korea South Asia South-East Asia Western Asia Education Epidemiology Screening and Intervention Toxicological Pathology Vol 5 2004 ASIAN PACIFIC JOURNAL of CANCER PREVENTION The Official Publication of the Asian Pacific Organization for Cancer Prevention An Official Journal of the International Association of Cancer Registries

3 Aims and Scope Asian Pacific Journal of Cancer Prevention Contents - Volume 1 - Volume 2 - Volume 3 - Volume 4 - Volume 5 Constitution Information for APJCP Information for Authors Information for Subscribers Events Members Aims and Scope The aim of the APOCP and its official journal the APJCP is to promote an increased awareness in all areas of cancer prevention and to stimulate practical intervention approaches. The scope is wide-ranging, including descriptive, analytical and molecular epidemiology, experimental and clinical histopathology/biology of preneoplasias and early neoplasias, assessment of risk and beneficial factors, experimental and clinical trials of primary preventive measures/agents, screening and secondary prevention, and all aspects of cancer prevention education. APJCP Chief Editor - APOCP Chairman Kazuo Tajima Division of Epidemiology and Prevention, Aichi Cancer Center, Research Institute 1-1 Kanokoden, Chikusa-ku, Nagoya 467-8681, Japan Tel +81-52-764-2986, Fax +81-52-763-5233 Email: APJCP Managing Editor - APOCP Coordination Director Malcolm A Moore Email: ASIAN PACIFIC ORGANIZATION for CANCER PREVENTION Subject Editor - Education/Cancer Registration Timothy J Threlfall (IARC Rep) Supannee Sriamporn Subject Editor - Epidemiology Shinkan Tokudome, Keun-Young Yoo Subject Editor - Screening and Intervention You-Lin Qiao, Iinuma Subject Editor - Toxicological Pathology Hiroyuki Tsuda, Yogeshwer Shukla

4 Areas of Interest

5 Cancer Registration

6 Descriptive Epidemiology: Males

7 Descriptive Epidemiology: Females

8 Prevalent Cancers

9 Consumption of Major Food Groups Worldwide as Percentages of Total Energy Dietary Variation

10 Histogenesis of Cancers and Prevention Timing

11 Individual Body Sites Cancer Type Prevalence over Time Risk Factors Beneficial Factors Primary Prevention Secondary Prevention Screening Modalities

12 Oral Cavity Cancer

13 Site Distribution and Factors Risk Factors Tobacco Betel Nut Trauma HPV/EBV Diet Protective Factors Antioxidants Oral Hygiene

14 Distribution of Betel Chewing

15 From Chiba, 2001 APJCP Histogenesis of Buccal Cancer

16 Oesophageal Cancer

17 Country LocationSCC ACRatio China, Tianjin33.1 3.310:1 China, Hong Kong84.5 9.3 9:1 India, Bombay91.9 1.092:1 India, Madras86.011.8 7:1 Israel, All Jews69.923.5 3:1 Japan, Miyagi92.2 3.229:1 Japan, Osaka90.3 3.824:1 Philippines, Manila67.118.3 4:1 Australia, NSW54.338.5 1:1 Australia, Victoria53.639.1 1:1 SCC:Adenocarcinoma Ratios for Oesophageal Cancer

18 Correlation between Cereal Intake and Oesophageal Cancer Risk Factors SCC Tobacco Opium Nutrient Deficiency Cereal Intake Adenocarcinoma Obesity

19 Prevention

20 Gastric Cancer


22 Factor Cardia Antrum Risk Helicobacter +/- +++ Epstein-Barr + +/- Gastric Ulcers +/- ++ High Salt Diet ++ +++ High fat Diet ++ +/- Obesity ++ +/- Smoking ++ + Alcohol + ++ Protective Vegetable Intake -- -- Data from the literature Risk and Protective Factors for Cancer of the Gastric Cardia and Antrum

23 Prevention

24 Colorectal Cancer

25 Correlation between Cereal Intake and Colon Cancer

26 Dietary Factors

27 Factors for Colon and Rectal Cancer Factor Colon Rectum Risk High fat Diet ++ ++ Obesity ++ +/- Alcohol +/- + Protective Physical Activity +++ +/- Fibre Intake ++ ++ (Data from Food, Nutrition and the Prevention of Cancer: a global perspective, World Cancer Research Fund/American Association for Cancer Research)

28 Colon or Rectal Cancer

29 Prevention

30 Hepatocellular Cancer

31 Lung Cancer


33 Cancer Site Linkage: Colon By Lung Adenocarcinoma Incidence/100,000

34 Lung Carcinoma Types Adenocarcinoma Hobnail Columnar/Cuboidal Mixed Polygonal Goblet Squamous Cell Carcinoma Tumour Behaviour Background Disease PathologyEpidemiology Molecular Biology Parameters Mutations Transversions Transitions Kinetics Apoptosis Proliferation Cell cycle/Signalling Polymorphisms Cancer Registration Hospital-based Population-based Risk/Beneficial Factors Tobacco Dietary Factors Cooking Environment Climate Lifestyle Anthropomorphic factors Genetic Background

35 Prevention

36 Urinary Bladder Cancer

37 Prostate Cancer

38 Prevention

39 Breast Cancer

40 Registry Age class 25-34 35-4445-54 55-6465-74 China, Tianjin4.515.515.813.5 6.9 India, Madras1.8 8.2 9.7 7.6 4.4 Japan, Osaka1.913.321.614.710.5 Phillipines, Manila5.015.816.812.9 7.0 Thailand, Khon Kaen1.3 4.5 4.5 2.8 1.1 Viet Nam, Hanoi2.7 9.111.0 5.1 1.1 Australia, Victoria5.225.338.337.541.8 *Incidence/100,000 x percentage of the female population # Data from Parkin et al., 1997 Age Dependence: Mammary cancer

41 Risk Factors

42 Prevention

43 Cervical Cancer

44 Risk Factors

45 Prevention

46 Data from Inoue and Tominaga, 2003 (APJCP) Lifetime Cumulative Risk: Japan

47 Sites Cancer control Methods/assumptions Direct All Primary preventionSmoking 17.5% 8.8% Chemoprevention?Dietary 25.6%10.3% Infection 13.9% 7.0% Subtotal26.1% Cancer screeningParticipation rates for gastric, colo-rectal, cervical, lung and breast cancer 30 to 50%29.4% 8.8-14.7% Improved diagnosis/ treatment5-year survival rate elevated by 0.6 - 1.0% per year for 10 years 6.0-10.0% Total 40.9-50.8% Potential for Prevention of Cancer Incidence/Deaths in Japan Data after Tominaga, 2001 (APJCP)

48 Practical Prevention Program

49 Who and Where?

50 Thank you!

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