1. Essential data for a complete dossier
so that this dossier can also be a strong basis for the derivation of EQS

2. Validity and sources of data
All data shall be quoted with exact and complete bibliographic reference, and the level of validation.
All data presented shall be validated:
at a European and/or international level (EU, OECD, US-EPA, etc.) OR
by the Stakeholders presenting the data
Any new data not validated at a European/international level but deemed to be of good quality and usable for the derivation of the EQS shall be reported, underlined and quoted, including the acceptance by any national program associated to a Klimisch code (Klimisch et al., 1997)
Klimisch, H. J., M. Andreae, et al. (1997). "A Systematic Approach for Evaluating the Quality of Experimental Toxicological and Ecotoxicological Data." Regulatory Toxicology and Pharmacology 25: 1-5.

3. Physico-chemical properties:
Solubility/Lipophility (KOW)
[experimental/calculated – QSAR used, reference]
Adsorption capacity (KOC)
Bioaccumulation (BCF)
Biomagnification (BMF1, BMF2)
[experimental / default value]

4. (Eco)toxicological data for derivation of QSwater_eco
(If available) Ecotoxicological data necessary for derivation of a PNEC -> an EQS, i.e.
at least:
1 acute ecotoxicity data on algae [
1 acute ecotoxicity data on invertebrates (crustaceans)
1 acute ecotoxicity data on fish
If possible:
As many chronic data as possible
[For all data, report : species, duration of the test, effect and no effect concentration, validation status, reference]

5. Toxicological data for derivation of Quality standards for protection of human health
At least 1 NOAEL or NOEC for derivation of QSbiota_sec pois
(If available) a toxicological reference value to evaluate the impact of the substance on mammalian species and the human, e.g.:
(Acute) Reference Dose ((A)RfD)
Tolerable/Acceptable Daily Intake (TDI/ADI)
Minimal Risk Level (MRL)
The most secure data shall be underlined in order to be used for the derivation of the QSbiota_hh
Any (regulatory) standard for water intended for human consumption for derivation of QSdw_hh
[For all data, report : species, duration of the test, dose, effect and no effect concentration, validation status, reference]

6. Do you have questions ?
Contact INERIS:
Alice James
Sandrine Andres