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Distinct parameters of the basophil activation test reflect the severity and threshold of allergic reactions to peanut  Alexandra F. Santos, MD, MSc,

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Presentation on theme: "Distinct parameters of the basophil activation test reflect the severity and threshold of allergic reactions to peanut  Alexandra F. Santos, MD, MSc,"— Presentation transcript:

1 Distinct parameters of the basophil activation test reflect the severity and threshold of allergic reactions to peanut  Alexandra F. Santos, MD, MSc, George Du Toit, FRCPCH, Abdel Douiri, PhD, Suzana Radulovic, MD, Alick Stephens, PhD, Victor Turcanu, PhD, Gideon Lack, MD, FRCPCH  Journal of Allergy and Clinical Immunology  Volume 135, Issue 1, Pages (January 2015) DOI: /j.jaci Copyright © 2014 The Authors Terms and Conditions

2 Fig 1 Peanut dose response of basophil activation in patients with severe versus nonsevere reactions (A) and in patients with low versus high threshold of reactivity (B) to peanut. *P < .05 and **P < .01 for the comparison between groups by using the Mann-Whitney U test. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2014 The Authors Terms and Conditions

3 Fig 2 Best BAT parameters to distinguish between patients with severe versus nonsevere reactions (A) and patients with low versus high threshold of reactivity (B) to peanut. **P < .01 and ***P < .001 for the comparison between groups by using the Mann-Whitney U test. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2014 The Authors Terms and Conditions

4 Fig 3 A, Proportion of patients with severe reactions according to the 75th percentile of basophil reactivity (measured by CD63 peanut/anti-IgE). B, Proportion of patients with lower threshold of reactivity to peanut according to the 75th percentile of basophil sensitivity (measured by using CD-sens). *P = .05 and **P < .01 for the comparison between groups by using the Mann-Whitney U test. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2014 The Authors Terms and Conditions


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