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Serial high-resolution computed tomography (HRCT) scans at the lung window from patient 4, who was treated with cladribine for progressive multisystem Langerhans cell histiocytosis. a, b) A predominant bullocystic pattern is observed in the lung bases. c, d... Serial high-resolution computed tomography (HRCT) scans at the lung window from patient 4, who was treated with cladribine for progressive multisystem Langerhans cell histiocytosis. a, b) A predominant bullocystic pattern is observed in the lung bases. c, d) Six months after treatment began, there was a substantial reduction in the extent of cystic lung lesions. e, f) Four years after treatment, lung abnormalities regressed substantially, with only residual fibrocystic lesions in the left lung base. Gwenaël Lorillon, and Abdellatif Tazi Eur Respir Rev 2017;26:170070 ©2017 by European Respiratory Society
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