1. Mechanical Prevention of Distal Embolization During Primary Angioplasty: Safety, Feasibility, and Impact on Myocardial Reperfusion
Ugo Limbruno, MD, PhD; Andrea Micheli, MD; Marco De Carlo, MD; Giovanni Amoroso, MD, PhD; Roberta Rossini, MD; Caterina Palagi, MD, PhD; Vitantonio Di Bello, MD; Anna Sonia Petronio, MD; Gabriella Fontanini, MD; Mario Mariani, MD
Circulation. 2003;108:

2. FilterWire-Ex in Primary PCI
106 patients with acute MI undergoing primary PCI
Matched Case-Control Study
FilterWire-Ex (FW)
A distal embolic protection device
Successfully positioned in 89% of patients without complication
(n = 53)
Matched Control
Matched for infarct-related artery, TIMI flow grade, gender and age
(n = 53)
Endpoints:
Primary – Feasibility and safety of adjunctive FW use during primary PCI
Secondary – Markers of effective reperfusion (ST resolution, myocardial blush grade, and cTFC); peak CK and CK-MB release, change in LVEF and WMSI at 30 days compared with admission; MACE (death, reinfarction, and need for target vessel revascularization) at 30 days
Circulation 2003; 108:

3. FilterWire-Ex in Primary PCI
Corrected TIMI Frame Count
p=0.005
Frames
Circulation 2003; 108:

4. FilterWire-Ex in Primary PCI
Myocardial Blush Grade 3
p=0.006
Circulation 2003; 108:

5. FilterWire-Ex in Primary PCI
ST-segment Resolution
p=0.006
Circulation 2003; 108:

6. FilterWire-Ex in Primary PCI
MACE at 30 Days
p=0.488
Circulation 2003; 108: