1. Progress Seminar
권순빈

2. 연구 진행 상황 보고서 2주전 계획 연구 결과 문제점 및 대책 목표 및 계획 CPF 정형외과
Alzheimer's disease 기타
2주전 계획 연구 결과
논문 제출 (JMIR mHealth and uHealth)
논문 제출 (Osteoarthritis and Cartilage)
논문 공부 + 연구 계획
문제점 및 대책
목표 및 계획

3. EEG and Alzheimer's Disease
Classical EEG features
Frequency and power
Non-classical EEG features
Network connectivity and activation
Auditory Event Related Potential
Amplitude and latency
P50
Theta-gamma coupling
TGC

4. Classical Features
Classical EEG features include amplitude, phase and power of different frequency bands; Gamma(30-100Hz), Beta(12-30Hz), Alpha(8-12Hz), Theta(4-8Hz), Delta(1-4Hz)
During the memory formation
Increase in Gamma power is observed in the task-related networks
Decrease in lower-frequency oscillation in multiple regions
During the resting EEG, mild AD patients showed
Lower alpha power compared to controls
Higher delta power compared to controls
During the rest EEG, AD patients showed
Increased delta global field power compared to controls
Increased theta global field power compared to controls
Reduced alpha global field power compared to controls
Reduced alpha global field power compared to MCI
Reduced beta global field power compared to MCI

5. Non-Classical Features
Default Mode Network (DMN)
Activated during inwardly oriented mental activity
Deactivated during outwardly directed mental tasks
Includes the precuneus, posterior cingulate cortex, regions of the temporal and medial prefrontal cortex
In cognitive disorders, deactivation of DMN components is impaired during learning
Reduced deactivation of DMN has been observed during memory-encoding test in normal individuals with cerebral amyloid deposits
Hippocampal hyperactivation
Hippocampal is essential for declarative memory
Hippocampal hyperactivation has been observed during memory-encoding test in normal individuals with cerebral amyloid deposits
Early hippocampal hyperactivation has been interpreted as a mechanism to compensate for emerging cognitive decline in early AD
Studies have suggested that there is a functional connection between DMN and hippocampus

6. Auditory Event Related Potential
Measure sensory gating
Reduced suppression of P50 is observed in patients with AD
P300
Only occurs if the subject is actively engaged in the task of detecting the targets
Amplitude was smaller and peak latency was longer for AD compared to controls
P600
Language-relevant ERP
Abnormal P600 was observed during ERP word repetition in mild AD patients
N400
Brain’s response to words or other meaningful stimuli
Abnormal N400 was observed during ERP word repetition in mild AD patients

7. Theta-Gamma Coupling
Lisman and co-workers have developed a multiplexing model explaining phase-coupled theta-gamma oscillations
Phase coupling of theta and gamma rhythms of EEG has been observed during working memory tasks
Previous study have reported external modulation of interaction between theta and gamma rhythms can improve the performance of working memory
Accuracy and modulation index during 2-back working memory task
Accuracy significantly differed between AD and control
Accuracy significantly differed between MCI and control
Accuracy did not significantly differed between AD and MCI
MI significantly differed between AD and control
MI significantly differed between AD and MCI
MI significantly differed between MCI and control

8. EEG Measurement Resting EEG Resting EEG Auditory ERP N-back test
Resting state
Classic features
Non-classic features
Working memory task
TGC
Auditory stimulations
Auditory ERP
Resting EEG
N-back test
Resting EEG
Auditory ERP

9. EEG Measurement Electrode Location Experiment / Measurement Condition
Resting state: system (19-20 electrodes)
TGC: system
P50: system
P300: system (Fz, Cz, and Pz)
DMN: 10-5 system or system with extra leads
Experiment / Measurement Condition
Resting state: Eyes closed
TGC: 2-back test
P50/P300: Auditory oddball task
In random order for 3 min/trials
1kHz standard tone
65 % of total stimulus
100ms duration
2kHz target tone
20 % of total stimulus
100ms duration
Press button for this tone
Individual’s threshold: 60 dB or above
Novel environmental tone
15% of total stimulus
200ms duration
Not presented in practice trial
0.1s
0.1s
0.2s
1~1.3s
1~1.3s

10. Alzheimer’s Disease Classification