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Submucosal uterine leiomyomas have a global effect on molecular determinants of endometrial receptivity  Beth W. Rackow, M.D., Hugh S. Taylor, M.D.  Fertility.

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Presentation on theme: "Submucosal uterine leiomyomas have a global effect on molecular determinants of endometrial receptivity  Beth W. Rackow, M.D., Hugh S. Taylor, M.D.  Fertility."— Presentation transcript:

1 Submucosal uterine leiomyomas have a global effect on molecular determinants of endometrial receptivity  Beth W. Rackow, M.D., Hugh S. Taylor, M.D.  Fertility and Sterility  Volume 93, Issue 6, Pages (April 2010) DOI: /j.fertnstert Copyright © 2010 American Society for Reproductive Medicine Terms and Conditions

2 Figure 1 Mean endometrial HOXA10 mRNA expression (normalized to β-actin). Endometrium was sampled from uteri without myomas (CTL), uteri with submucosal myomas (SM = biopsy from endometrium over normal myometrium; DSM = directed biopsy from endometrium overlying submucosal myoma), and uteri with intramural myomas (IM). ∗P<.05 compared with intramural myoma and control groups. Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2010 American Society for Reproductive Medicine Terms and Conditions

3 Figure 2 Endometrial HOXA10 immunohistochemistry. Immunohistochemistry identified HOXA10 protein expression in endometrial glands and stroma. H-SCOREs were determined separately for the glands and stroma. Shown are representative photomicrographs demonstrating HOXA10 expression in endometrium in the setting of (A) submucosal myoma, (B) intramural myoma, (C) no myomas, and (D) HOXA10-negative control omitting primary antibody. Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2010 American Society for Reproductive Medicine Terms and Conditions

4 Figure 3 Mean endometrial HOXA11, BTEB1, and LIF mRNA expression (normalized to β-actin). Endometrium was sampled from uteri without myomas (CTL), uteri with submucosal myomas (SM), and uteri with intramural myomas (IM). ∗P< .05. Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2010 American Society for Reproductive Medicine Terms and Conditions


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