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Laurence J. Egan  Clinical Gastroenterology and Hepatology 

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Presentation on theme: "Laurence J. Egan  Clinical Gastroenterology and Hepatology "— Presentation transcript:

1 Drug interactions in gastroenterology: Mechanisms, consequences, and how to avoid 
Laurence J. Egan  Clinical Gastroenterology and Hepatology  Volume 2, Issue 9, Pages (September 2004) DOI: /S (04)00343-X Copyright © 2004 American Gastroenterological Association Terms and Conditions

2 Figure 1 The omeprazole-itraconazole interaction is caused by a pharmacokinetic mechanism at the level of itraconazole absorption. Clinical Gastroenterology and Hepatology 2004 2, DOI: ( /S (04)00343-X) Copyright © 2004 American Gastroenterological Association Terms and Conditions

3 Figure 2 The methotrexate-ibuprofen interaction is caused by a pharmacokinetic mechanism at the level of methotrexate excretion. Clinical Gastroenterology and Hepatology 2004 2, DOI: ( /S (04)00343-X) Copyright © 2004 American Gastroenterological Association Terms and Conditions

4 Figure 3 The cyclosporine-grapefruit juice interaction is caused by a pharmacokinetic mechanism at the level of cyclosporine first-pass metabolism. Clinical Gastroenterology and Hepatology 2004 2, DOI: ( /S (04)00343-X) Copyright © 2004 American Gastroenterological Association Terms and Conditions

5 Figure 4 The azathioprine-allopurinol interaction is caused by a pharmacokinetic mechanism at the level of azathioprine metabolism. Clinical Gastroenterology and Hepatology 2004 2, DOI: ( /S (04)00343-X) Copyright © 2004 American Gastroenterological Association Terms and Conditions

6 Figure 5 The warfarin-phenobarbital interaction is caused by a pharmacokinetic mechanism at the level of warfarin inactivation. Clinical Gastroenterology and Hepatology 2004 2, DOI: ( /S (04)00343-X) Copyright © 2004 American Gastroenterological Association Terms and Conditions

7 Figure 6 The warfarin-aspirin interaction is caused by a combination of pharmacodynamic mechanisms that result in greater anticoagulant effects. Clinical Gastroenterology and Hepatology 2004 2, DOI: ( /S (04)00343-X) Copyright © 2004 American Gastroenterological Association Terms and Conditions

8 Figure 7 The furosemide-indomethacin interaction is caused by a pharmacodynamic mechanism at the level of renal sodium handling. Clinical Gastroenterology and Hepatology 2004 2, DOI: ( /S (04)00343-X) Copyright © 2004 American Gastroenterological Association Terms and Conditions

9 Figure 8 The cause of the selegiline-meperidine interaction is obscure. Clinical Gastroenterology and Hepatology 2004 2, DOI: ( /S (04)00343-X) Copyright © 2004 American Gastroenterological Association Terms and Conditions


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