1. One lung anesthesia
Dr. S. Parthasarathy MD., DA., DNB, MD (Acu), Dip. Diab. Dip. Software statistics PhD ( physiology), IDRA , FICA

2. Its quite big topic ! I am just touching ! The foundation is
Hypoxic pulmonary vasoconstriction

3. Hypoxic pulmonary vasoconstriction

4. When does it ( hypoxia )occur
Humans encounter hypoxia throughout their lives.
This occurs by
destiny in utero,
disease,
desire, in our quest for himalayas !

5. What is it and why ? Reduces shunt fraction Optimizes PO2
HPV = homeostatic, vasomotor response of resistance of pulmonary arteries to alveolar hypoxia

6. What happens ! total pulmonary blood flow α RV cardiac output,
within the pulmonary vasculature can be altered dynamically.
Hypoxia diverts blood flow to better ventilated, non hypoxic lung segments.
This phenomenon of HPV, first noted by Von Euler and Liljestrand in 1946

7. With this base , we will switch to OLV
This is a biphasic reaction with early response starting within seconds, reaching a peak at about 15 min followed by a delayed response in 4 h to cause maximal vasoconstriction…
this pulmonary vasoconstriction takes hours to reverse when normoxia returns. 
With this base , we will switch to OLV

9. When switching from two-lung to one-lung ventilation (OLV), shunt fraction increases, oxygenation is impaired, and hypoxemia may occur
hypoxemia may occur in 5–10% of patients undergoing OLV

10. Normal lung four zones

11. Normal lung in lateral position
Upright : R:L 55:45
Right dependent –
R; L 65: 35
Left dependent
R:L = 45:55
Ventilation – dome of the dependent diaphragm becomes more convex – better contraction

12. Patient Anesthetized, Chest Closed
Not much change in perfusion
Compression by the weight of the mediastinum and the abdominal contents contribute to the decrease in FRC of the dependent lung
the nondependent lung receives most of the ventilation but still is less perfused, whereas the dependent lung receives less ventilation but continues to be more perfused, which leads to an increase in shunt

14. Patient Anesthetized, Paralyzed, Mechanically Ventilated
With mechanical ventilation, the highly curved diaphragm in the dependent hemithorax – advantage gone - it is no longer actively contracting.
The weight of the abdominal viscera physically restricts expansion of the dependent lung, leading to further preferential distribution of ventilation to the nondependent, less-perfused lung.

15. Open the chest !
Ventilation may be more but more so in non dependent lung !
The decrease in airway pressure on opening the pleura, along with the increase in cardiac index, results in increased blood flow to the nondependent lung.
Exit of CO2 from non dependent lung

16. Summary
Continue !
The anesthetized, paralyzed patient in the lateral decubitus position with an open chest may have considerable V/Q mismatch.
The nondependent lung receives greater ventilation and less perfusion and has a V/Q ratio of more than 1.
The dependent lung has more perfusion and less ventilation (ie, a low V/Q ratio) and therefore acts as a physiologic shunt.

17. Starting OLV
Back to HPV !!
We have not started OLV

18. A good preoperative spirometry usually predicts bad intra operative hypoxemia
A- a O2 gradient is normal – hypoxemia chance more
Side

19. Three knots of one lung anesthesia
Oxygenation ( diffusion )
CO2 removal (Ventilation)
Anesthesia

21. Picture clear ?

22. Redox theory Redox sensor activated Reactive oxygen species
Metabolic acidosis
Respiratory acidosis
Hyperthermia
Redox sensor activated
Reactive oxygen species
Decrease K channels
Stimulate calcium channels
HPV
increases in PA pressure,
cardiac output, left atrial pressure, or central blood volume
HPV

23. Does the PA pressure rise after HPV ?
High compliance of the pulmonary circulation prevents clinically significant changes in pulmonary vascular resistance or PA pressure

24. Hypocapnia and hypothermia decrease HPV response
Inhalational agents decrease but actual effect – significance ??
Ketamine , propofol and thoracic epidurals does not affect much

25. Nitric oxide and inhaled prostacyclins Selective pulmonary vasodilators can improve V/Q mismatch in lung surgeries

26. One lung ventilation Prone for hypoxemia
We are better when faced with infective cause and destroyed lungs than carcinoma
OLV for esophagectomy and bronchiectasis – different
Lungs are destroyed prior , the patient tolerates OLV better !!

27. They have compensated and knew to live ?
Better
They have compensated and knew to live
but normal lungs by the side – more prone for hypoxemia

28. Principles of OLV - oxygenation
Delay OLV as possible – allow the non dependent lung to collapse !
Suction , Check DLT position
Increase FiO2 to get atleast 90 % saturation
Increase respiratory rate , tidal volume but check on pressure to be less than 30 mmHg ( barotrauma)
Plan for a PaCO2 < 35 mmHg
Increased ventilation may wash out CO2 ! Beware

29. The ETCO2 may be showing differently
Paco2 – may be different
See the difference at the start
Then at least we can correlate
Otherwise only ABG

30. Special !!
Special ventilators employing instantaneous breath-to-breath analysis to adjust ventilatory patterns (adaptive lung ventilation) have been used during one-lung ventilation
Is there a development of Auto PEEP ?

31. There is no agreed standard for the definition of hypoxemia during OLV; however, an arterial oxygen saturation of less than 90% with an Fio2 of 1.0 is commonly accepted as a level at which some intervention by the attending anesthesiologist is required.
Key strategies
To decrease hypoxemia

32. Oxygen !!
Direct insufflation of oxygen to the non dependent lung kept in the carina or just above

33. PREVENTION OF ABSORPTION ATELECTASIS
100 % oxygen causes absorption atelectasis
Why ?
What Goes in > what comes out from the lungs
Combine N2 10 % with oxygen
Nitrogen ( less soluble than nitrous ) splits open the alveoli in areas of low V/Q ratio.

34. Cut nitrous ! Then MAC will be high
Cut agent to inhibit action on HPV
Then are we giving anesthesia or not
Think of less agents at least with IVA

35. VERIFICATION OF LUNG ISOLATION
Check double lumen tube position
Suction secretions
Get the airway pressure down

36. RECRUITMENT MANEUVER Sigh!!
single-lung ventilation, lateral decubitus positioning, inhibition of HPV, and periodic disconnection from the ventilator
A sustained pressure of about 35 to 40 cm H2O, which would be above the tidal ventilation range, is applied for a period of 30 to 60 seconds in order to inflate lung units.
40/40 !!
Sigh!!

37. VENTILATION USING LARGE TIDAL VOLUMES
Start with 6- 8 ml/kg – increase or decrease with ABG and airway pressures
Increased airway pressures with the associated the risks barotrauma and increased PVR can divert blood, that is, perfusion, to the non ventilated nondependent lung…
Post op pulmonary edema in high inflation pressures !

38. Maintain PaCO2 !
Hypocapnia should be avoided because it can directly dilate the pulmonary vessels, interfering with HPV in the nondependent lung.
Alternatively, hypercapnia will increase PVR and can increase right heart strain
CO2 diffuse easily !

39. SELECTIVE NONDEPENDENT-LUNG CPAP
Expand with higher pressure for two three puffs and then start CPAP
20 % blood flow becomes 24 % with isoflurane –
5 – 10 cm CPAP may oxygenate these areas without surgical interference

40. With or without reservoir bags !

41. In most situations, an O2 flow rate of 5 to 10 L/min, which creates CPAP of 5 to 10 cm H2O, is sufficient for improving oxygenation.
Mediastinal shift and penduluft ventilation
Not failed bronchial seal !!
Keep oxygen instead of air !!

42. DEPENDENT-LUNG PEEP

43. DEPENDENT-LUNG PEEP Diseased lung may be more useful
But healthy lungs ? Use may harm ?
COPD – both are disaeased but bullectomy on one side – that case , PEEP may open up !!

44. continuous high-flow apneic ventilation
A very high O2 flow rate delivered at or below the carina may improve gas exchange without any tidal exchange, which is known as
“continuous high-flow apneic ventilation.”

45. Other techniques !
If hypoxemia still persists after differential CPAP/PEEP, the nondependent lung may be intermittently ventilated with positive pressure and 100% O2.
Selective non dependent HFV
Clamp the pulmonary artery

46. Titbits
Because the right lung is larger than the left lung, it is seen that oxygenation during OLV is better during left thoracotomy
(i.e., when the larger right lung is the dependent, ventilated lung).
In concentrations ranging from 5 to 40 ppm, nitric oxide did not improve oxygenation or decrease the occurrence of hypoxemia during OLV.

47. Titbits
The combination of NO (20 ppm) to the ventilated lung and an intravenous infusion of Almitrene (a pulmonary vasoconstrictor) can restore PaO2 during OLV to levels close to these during two-lung ventilation
Epidural may not benefit
Better hemoglobin is better
Some patients, particularly those with COPD, showed better oxygenation during OLV with a pressure controlled vs volume controlled ventilation.

49. Thank you all