1. OPTN Histocompatibility Committee
Spring 2019

2. Recently Approved Proposals
Board Approval
Implementation Date
Addressing HLA Typing Errors
Reduce instances of data entry errors for HLA typing
December 2018
See below
March 1, 2019
OPO submitting source documentation for donor HLA tying in DonorNet
Updated written agreements between OPOs and Histocompatibility Labs to include verification of HLA entry.
Pending programming/notice to members
New double entry for HLA results that are entered manually
The proposal to Address HLA Typing Errors was approved by the Board in December The goal of this proposal is to increase patient safety through common-sensed verification processes. This proposal applies when:
HLA data is entered manually into UNet, it must be entered twice (by the same person) for verification of accurate data entry
HLA data are uploaded directly into UNet, the member must have a process for verifying that the data are accurate
Raw HLA typing must be attached in the system for verification of lab results
There are two phases of implementation for this proposal. The first phase includes those changes that can be implemented quickly and not dependent on programming. This includes OPOs submitting source documentation for donor HLA typing in DonorNet, and updating written agreements between OPOs and histocompatibility labs to address new policy requirements. The second phase of implementation includes the functionality for double entry in DonorNet.

3. Recently Implemented Proposals
Status
Review of HLA Tables (2016)
Provide new alleles and HLA-DPB1 unacceptable antigen equivalency table
Implemented December 2018
This proposal aligned tables in OPTN Policy 4 with vendor test kits.

4. Ongoing Proposals Proposal Change CPRA Calculation Under development
Status
Change CPRA Calculation
Committee reviewing data for new calculation
Evaluating “donor count” method vs. enhancing current haplotype method w/ expanded data
Examining possible integration of data from the National Marrow Donor Program
Under development
Public comment target 1/2020
The Committee continues to develop this proposal in collaboration with experts familiar with the National Marrow Donor Program data. The goal of this project is to improve donor-potential recipient HLA matching.

5. Future Initiatives Proposal Strategic Goals Review HLA Tables (2019)
Update reference tables in Policy 4.10 to be consistent with current testing methods
Evaluating inclusion of CWD alleles for DPB1 equivalency table
Increase Equity in Access to Transplants
Improve Patient Safety
This new project includes not only updates to be consistent with vendor test kits, but also the inclusion of DPB and CWD alleles.

6. Questions Cathi Murphey, Ph.D., HCLD/CC(ABB) Committee Chair
Christopher L. Wholley, M.S.A.
Transplant Community Administrator