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Brain glucose metabolism lowers plasma triglycerides

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Presentation on theme: "Brain glucose metabolism lowers plasma triglycerides"— Presentation transcript:

1 Brain glucose metabolism lowers plasma triglycerides
Tony K T Lam, et al. Nature Medicine 2007;13:171-80

2 Effect of central glucose metabolism on VLDL secretion
Tony K T Lam, et al. Nature Medicine 2007;13:171-80

3 Brain glucose metabolism inhibits hepatic SCD1 activity
Tony K T Lam, et al. Nature Medicine 2007;13:171-80

4 Effect of hepatic SCD1 activity and oleyl-CoA on VLDL secretion
Tony K T Lam, et al. Nature Medicine 2007;13:171-80

5 Brain glucose, but not lactate, administration does not inhibit plasma triglyceride levels and hepatic VLDL secretion in overfed rats Tony K T Lam, et al. Nature Medicine 2007;13:171-80

6 Hypothalamic sensing of circulating lactate is required to inhibit hepatic TG-VLDL secretion
Tony K T Lam, et al. Nature Medicine 2007;13:171-80

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