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Volume 86, Issue 6, Pages (December 2014)

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1 Volume 86, Issue 6, Pages 1197-1204 (December 2014)
Data from a large European study indicate that the outcome of primary hyperoxaluria type 1 correlates with the AGXT mutation type  Giorgia Mandrile, Christiaan S. van Woerden, Paola Berchialla, Bodo B. Beck, Cécile Acquaviva Bourdain, Sally-Anne Hulton, Gill Rumsby  Kidney International  Volume 86, Issue 6, Pages (December 2014) DOI: /ki Copyright © 2014 International Society of Nephrology Terms and Conditions

2 Figure 1 Patient survival of the entire cohort; Kaplan–Meier survival curve.       Kidney International  , DOI: ( /ki ) Copyright © 2014 International Society of Nephrology Terms and Conditions

3 Figure 2 Censored Kaplan–Meier curves for age at onset of end-stage renal disease (ESRD) for each genotype class. Data were available for 355 patients; log-rank test P-value <0.001. Kidney International  , DOI: ( /ki ) Copyright © 2014 International Society of Nephrology Terms and Conditions

4 Figure 3 Hazard ratios of age at onset of end-stage renal disease adjusted for gender (estimated with Cox model). Reference group is G170R homozygotes. The following confidence levels are shown: 0.9, 0.95, and 0.99, using different tone of gray (from darkest to lightest). Kidney International  , DOI: ( /ki ) Copyright © 2014 International Society of Nephrology Terms and Conditions

5 Figure 4 Ranking of missense mutations. Ranking of patient subgroups carrying the same missense mutation ordered according to their median (a) age at onset and (b) age at end-stage renal disease either in homozygous state (left panels), compound heterozygous state with G170R (middle panels), or in compound heterozygous with a null mutation (right panel). The number of patients with the relevant mutation is given in parentheses. Missense mutations are coded as follow: Kidney International  , DOI: ( /ki ) Copyright © 2014 International Society of Nephrology Terms and Conditions

6 Figure 4 Ranking of missense mutations. Ranking of patient subgroups carrying the same missense mutation ordered according to their median (a) age at onset and (b) age at end-stage renal disease either in homozygous state (left panels), compound heterozygous state with G170R (middle panels), or in compound heterozygous with a null mutation (right panel). The number of patients with the relevant mutation is given in parentheses. Missense mutations are coded as follow: Kidney International  , DOI: ( /ki ) Copyright © 2014 International Society of Nephrology Terms and Conditions

7 Kidney International 2014 86, 1197-1204DOI: (10.1038/ki.2014.222)
Copyright © 2014 International Society of Nephrology Terms and Conditions


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