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Volume 138, Issue 1, Pages (January 2010)

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Presentation on theme: "Volume 138, Issue 1, Pages (January 2010)"— Presentation transcript:

1 Volume 138, Issue 1, Pages 89-97 (January 2010)
Phenotypic Variation of Colonic Motor Functions in Chronic Constipation  Karthik Ravi, Adil E. Bharucha, Michael Camilleri, Deborah Rhoten, Timothy Bakken, Alan R. Zinsmeister  Gastroenterology  Volume 138, Issue 1, Pages (January 2010) DOI: /j.gastro Copyright © 2010 AGA Institute Terms and Conditions

2 Figure 1 Comparison of colonic compliance (Pr50) among categories. Among patients without DD, Pr50 was lower in STC than NTC. However, among patients with DD, Pr50 was comparable in DD-NTC and DD-STC. The horizontal line is the 10th percentile value in healthy subjects. Gastroenterology  , 89-97DOI: ( /j.gastro ) Copyright © 2010 AGA Institute Terms and Conditions

3 Figure 2 Normal fasting, postprandial and postneostigmine tonic, and phasic colonic motor activity in a patient with STC. Observe reduced balloon volume, reflecting increased colonic tone, after a meal and after neostigmine. Manometry showed increased phasic pressure activity in the sigmoid colon after a meal and also in the descending colon after neostigmine. The principal component analysis revealed a high score for factor 2. Gastroenterology  , 89-97DOI: ( /j.gastro ) Copyright © 2010 AGA Institute Terms and Conditions

4 Figure 3 Impaired colonic tonic contractile responses to a meal and neostigmine in a patient with STC. In contrast, manometry revealed increased fasting and postprandial phasic pressure activity. The principal component analysis revealed a high score for factor 1. Gastroenterology  , 89-97DOI: ( /j.gastro ) Copyright © 2010 AGA Institute Terms and Conditions


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