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Increased Numbers of Eosinophils, Rather Than Only Etiology, Predict Histologic Changes in Patients With Esophageal Eosinophilia  Srividya Sridhara, Karthik.

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Presentation on theme: "Increased Numbers of Eosinophils, Rather Than Only Etiology, Predict Histologic Changes in Patients With Esophageal Eosinophilia  Srividya Sridhara, Karthik."— Presentation transcript:

1 Increased Numbers of Eosinophils, Rather Than Only Etiology, Predict Histologic Changes in Patients With Esophageal Eosinophilia  Srividya Sridhara, Karthik Ravi, Thomas C. Smyrk, Hirohito Kita, Gail M. Kephart, Catherine R. Weiler, David A. Katzka  Clinical Gastroenterology and Hepatology  Volume 10, Issue 7, Pages (July 2012) DOI: /j.cgh Copyright © 2012 AGA Institute Terms and Conditions

2 Figure 1 Staining for (A) EDN and (B) MBP in the same area of biopsy in a patient with GERD. (C) Linear MBP staining pattern in a patient with EoE. Clinical Gastroenterology and Hepatology  , DOI: ( /j.cgh ) Copyright © 2012 AGA Institute Terms and Conditions

3 Figure 2 EDN staining. (A) EoE patient with grade 3 extracellular staining (white rectangles) and grade 2 intracellular staining (white circles). (B) GERD with grade 3 intracellular and grade 1 extracellular staining. (C) Barrett's esophagus with grade 2 intracellular and extracellular staining. Clinical Gastroenterology and Hepatology  , DOI: ( /j.cgh ) Copyright © 2012 AGA Institute Terms and Conditions

4 Figure 3 Staining for (A) EDN and (B) tryptase (brown staining) in the same biopsy location for an EoE patient. Clinical Gastroenterology and Hepatology  , DOI: ( /j.cgh ) Copyright © 2012 AGA Institute Terms and Conditions

5 Figure 4 Peak mast cells/HPF vs peak eosinophils/HPF by group. Group 0, EoE; group 1, GERD; and group 2, Barrett's. Clinical Gastroenterology and Hepatology  , DOI: ( /j.cgh ) Copyright © 2012 AGA Institute Terms and Conditions


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