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Joseph H. Antin, Allen R. Chen, Daniel R. Couriel, Vincent T

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Presentation on theme: "Joseph H. Antin, Allen R. Chen, Daniel R. Couriel, Vincent T"— Presentation transcript:

1 Novel approaches to the therapy of steroid-resistant acute graft-versus-host disease 
Joseph H. Antin, Allen R. Chen, Daniel R. Couriel, Vincent T. Ho, Richard A. Nash, Daniel Weisdorf  Biology of Blood and Marrow Transplantation  Volume 10, Issue 10, Pages (October 2004) DOI: /j.bbmt Copyright © 2004 American Society for Blood and Marrow Transplantation Terms and Conditions

2 Figure 1 Available agents targeting human IL-2R: agents targeting activated T cells through the IL-2 receptor. For the 3 monoclonal antibodies, red indicates murine structural elements, and red is the humanized portion. For denileukin diftitox, gray represents the IL-2 molecule, and black represents the diphtheria toxin moiety. Comp/ADCC, complement activation/antibody-dependent cellular cytotoxicity; RE-blockade, reticuloendothelial blockade. Figure is adapted courtesy of Dr. Fred LeMaistre. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2004 American Society for Blood and Marrow Transplantation Terms and Conditions


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