Presentation is loading. Please wait.

Presentation is loading. Please wait.

Figure 4 Comparison of 7.0T and 3.0T MRI (patients 5 and 6)‏

Published byNickolas Malone Modified over 5 years ago

Similar presentations

Presentation on theme: "Figure 4 Comparison of 7.0T and 3.0T MRI (patients 5 and 6)‏"— Presentation transcript:

1 Figure 4 Comparison of 7.0T and 3.0T MRI (patients 5 and 6)‏
Comparison of 7.0T and 3.0T MRI (patients 5 and 6) T1-weighted images of patient 5 at 3.0T and 7.0T are shown. Owing to substantially increased signal-to-noise ratio, 7.0T T1-weighted magnetization-prepared rapid gradient echo delineates numerous T1-weighted hypointense lesions within the pons and cerebellum (arrowheads, E–G). In contrast, corresponding areas appear normal (C, D) or only marginally hypointense on T1-weighted images at 3.0T (circle, A, B). T1-weighted hypointensity within non-contrast-enhancing chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids lesions may indicate postinflammatory structural brain damage including axonal loss on top of demyelination. Immunohistochemical stainings of autopsy case for neurofilament (NF) revealed massive axonal injury in the inflammatory lesion of the brainstem (H; CD3 red, NF brown) compared to insular cortex with limited inflammation (J). The presence of phosphorylated NF in the perinuclear cytoplasm of neurons suggests retrograde neuronal degeneration due to axonal injury in the lesions (H). Similarly, severe loss of perivascular myelin was found in areas of severe inflammation (I), compared to areas with limited inflammation (K), with Luxol fast blue and hematoxylin & eosin. 7.0T = 3D T1-weighted magnetization-prepared rapid gradient echo at 7.0T, echo time = 2.98 ms, repetition time = 2,300 ms, inversion time = 900 ms, spatial resolution = 1.0 × 1.0 × 1.0 mm3; 3.0T = standard T1-weighted axial images (B–D) and T1-weighted magnetization-prepared rapid gradient echo at 3.0T (A). 3.0T and 7.0T MRI examinations were performed 3 days apart. Magnification 10× (H–K). Scale bar = 100 μm. Morten Blaabjerg et al. Neurol Neuroimmunol Neuroinflamm 2016;3:e226 © 2016 American Academy of Neurology

Download ppt "Figure 4 Comparison of 7.0T and 3.0T MRI (patients 5 and 6)‏"

Similar presentations

Axonal loss in the pathology of MS: consequences for understanding the progressive phase of the disease  C Bjartmar, J.R Wujek, B.D Trapp  Journal of.

Axonal loss in the pathology of MS: consequences for understanding the progressive phase of the disease  C Bjartmar, J.R Wujek, B.D Trapp  Journal of.
Figure 2. A patient with multifocal nodular lesions diagnosed with CNS tuberculosis A patient with multifocal nodular lesions diagnosed with CNS tuberculosis.

Figure 2. A patient with multifocal nodular lesions diagnosed with CNS tuberculosis A patient with multifocal nodular lesions diagnosed with CNS tuberculosis.
Figure 1 Initial brain imaging (A–C) patient 1; (D–F) patient 2; (G–I) patient 3; (J–L) patient 4; and (M) patient 2. Initial brain imaging (A–C) patient.

Figure 1 Initial brain imaging (A–C) patient 1; (D–F) patient 2; (G–I) patient 3; (J–L) patient 4; and (M) patient 2. Initial brain imaging (A–C) patient.
Figure 3 Brain MRI findings in patients with MOG-Ab Extensive brain lesions with large diameter (A and B), posterior reversible encephalopathy–like lesions.

Figure 3 Brain MRI findings in patients with MOG-Ab Extensive brain lesions with large diameter (A and B), posterior reversible encephalopathy–like lesions.
Figure 1 Brain MRI findings in the present case

Figure 1 Brain MRI findings in the present case
Figure 4. Brain imaging and neuropathologic demonstration of Epstein-Barr virus (EBV) encephalitis in patient PT-10 Brain imaging and neuropathologic demonstration.

Figure 4. Brain imaging and neuropathologic demonstration of Epstein-Barr virus (EBV) encephalitis in patient PT-10 Brain imaging and neuropathologic demonstration.
Figure 2 Orbital MRI findings One-third of myelin oligodendrocyte glycoprotein antibody–positive patients revealed extensive enhancement patterns that.

Figure 2 Orbital MRI findings One-third of myelin oligodendrocyte glycoprotein antibody–positive patients revealed extensive enhancement patterns that.
Figure Neuroimaging and pathology

Figure Neuroimaging and pathology
Figure 3 Immunohistochemical analyses of positive and negative Epstein-Barr virus (EBV) control tissues using immunostaining Immunohistochemical analyses.

Figure 3 Immunohistochemical analyses of positive and negative Epstein-Barr virus (EBV) control tissues using immunostaining Immunohistochemical analyses.
Figure Facial photograph during headache attack and brain and upper cervical cord MRI Facial photograph during headache attack and brain and upper cervical.

Figure Facial photograph during headache attack and brain and upper cervical cord MRI Facial photograph during headache attack and brain and upper cervical.
Figure 3 Example of venous narrowing

Figure 3 Example of venous narrowing
Figure 2 Immunopathologic analysis of all 3 Rasmussen encephalitis cases Immunopathologic analysis of all 3 Rasmussen encephalitis cases (A) Perivascular.

Figure 2 Immunopathologic analysis of all 3 Rasmussen encephalitis cases Immunopathologic analysis of all 3 Rasmussen encephalitis cases (A) Perivascular.
Figure 1 Histopathologic features of a chronic active and a chronic plaque in the MS brain Histopathologic features of a chronic active and a chronic plaque.

Figure 1 Histopathologic features of a chronic active and a chronic plaque in the MS brain Histopathologic features of a chronic active and a chronic plaque.
Figure Radiographic and histopathologic findings (A) Brain MRI at presentation shows multiple areas of T2 hyperintensity in the mesial temporal lobes,

Figure Radiographic and histopathologic findings (A) Brain MRI at presentation shows multiple areas of T2 hyperintensity in the mesial temporal lobes,
Figure Clinical presentation of daclizumab side effects with skin rash and meningoencephalomyelitis Clinical presentation of daclizumab side effects with.

Figure Clinical presentation of daclizumab side effects with skin rash and meningoencephalomyelitis Clinical presentation of daclizumab side effects with.
Figure Brain MRI and biopsy specimens from the pontine lesion

Figure Brain MRI and biopsy specimens from the pontine lesion
Figure Longitudinal MRI study data demonstrating evolution of central pontine myelinolysis(A, B) Axial T2-weighted MRI of the brain from January 9, 2014,

Figure Longitudinal MRI study data demonstrating evolution of central pontine myelinolysis(A, B) Axial T2-weighted MRI of the brain from January 9, 2014,
Figure 5. A patient with focal pachymeningitis and Tolosa-Hunt-like syndrome A patient with focal pachymeningitis and Tolosa-Hunt-like syndrome (A) Neuroimaging.

Figure 5. A patient with focal pachymeningitis and Tolosa-Hunt-like syndrome A patient with focal pachymeningitis and Tolosa-Hunt-like syndrome (A) Neuroimaging.
Figure 2 Brain biopsy Brain biopsy (A) Double staining with anti-aquaporin-4 (AQP4) antibody (dark green) and Luxol fast blue (blue) is shown. Loss of.

Figure 2 Brain biopsy Brain biopsy (A) Double staining with anti-aquaporin-4 (AQP4) antibody (dark green) and Luxol fast blue (blue) is shown. Loss of.
Figure Nuclear Nrf2 expression after fumarate therapy A new left occipital fluid-attenuated inversion recovery hyperintense (A), T1 hypointense (B), and.

Figure Nuclear Nrf2 expression after fumarate therapy A new left occipital fluid-attenuated inversion recovery hyperintense (A), T1 hypointense (B), and.

Similar presentations

Ads by Google