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Robert Benezra, Shahin Rafii  Cancer Cell 

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Presentation on theme: "Robert Benezra, Shahin Rafii  Cancer Cell "— Presentation transcript:

1 Endostatin's endpoints—Deciphering the endostatin antiangiogenic pathway 
Robert Benezra, Shahin Rafii  Cancer Cell  Volume 5, Issue 3, Pages (March 2004) DOI: /S (04)

2 Figure 1 The angiogenic balance
Endostatin tips the scale toward angiogenesis inhibition by inhibiting the activity/expression of proangiogenic factors and stimulating antiangiogenic factors both at the cell surface and intracellularly. The arrows with question marks indicate our lack of understanding about signaling interdependencies versus parallel effects of endostatin. Cancer Cell 2004 5, DOI: ( /S (04) )


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