1. CVRG Presenter Disclosure Information Joel Saltz MD, PhD Director Comprehensive Informatics Center Emory University Translational Research Informatics and CVRG FINANCIAL DISCLOSURE: None UNLABELED/UNAPPROVED USES DISCLOSURE: None 1

2. CVRG Translational Research Informatics Gender Ethnicity Age Weight Diagnosis Medical History Literature Databases Terminologies Ontologies Lab Tests Genes Proteins Biological Models Technologies Algorithms Integration, Management, Analysis, and Dissemination

3. CVRG Translational Research Continuum SNP Identification Clinical Data Correlation Expression Analysis Tissue Banking Study Creation Patient Enrollment Clinical Data Collection Image Sharing & Analysis Slide from Ken Buetow

4. CVRG Transcontinental Railway: The Golden Spike - Triumph of Standards

5. CVRG Translation: Same ideas, different words

6. CVRG Biomedical Informatics Services Security Semantic interoperability – common vocabulary and meaning Data structure interoperability Interoperability with existing standards for clinical and imaging systems (e.g. HL-7, DICOM) Ability to compose services to create application Ability to efficiently invoke high end computing services Coordinated query to obtain data from many datasources 6

7. CVRG Biomedical Grid Organizations

8. CVRG Distinguishing Informatics Aspects of CVRG Annotation, markup and query of time dependent imagery Electrophysiology ECG: grid based data storage, query and analysis Cardiac research related semantics

9. CVRG caBIG Organization Structure Architecture Vocabulary & Common Data Elements General Contractor Strategic Working Groups Clinical Trials Integrative Cancer Research Tissue Banks & Pathology Tools caBIG Oversight Imaging Open to all, not just funded participants. 190 institutions, 2000 people involved thus far.

10. CVRG caBIG Middleware: caGrid caGrid Components Advertisement and Discovery Workflow Security (GAARDS) Language (metadata, ontologies) Grid Service Graphical Development Toolkit (Introduce) Wrapping executables (gRavi) Efficient Bulk Data Transport (IVI middleware) DICOM compatability (IVI middleware)

11. CVRG caGrid Service Common Application Services 11 caGrid Service MRI/CT Images DICOM/AIM Model CVRG Grid Infrastructure caGrid Service Taqman Data JHU SNP Model caGrid Service ECG XML HL7 aECG Model caGrid Service Physionet WFDB WFDB Metadata Model caGrid Service OpenClinica Data OpenClinica Model caGrid Service ProteinDB Data ProteinDB Model Physionet Algorithms Berger QT Algorithm

12. CVRG CVRG Challenge: Temporal Data ECG, Cardiac MRI, Multi-slice Cardiac CT, Cardiac PET/CT, Nuclear Perfusion Imaging … Analysis and integration of cardiac electrical, mechanical activity, perfusion and hemodynamics Temporal query and analysis across patient populations Integration with clinical and omic data