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Latest Perspectives in PAD: How to Improve Outcomes

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Presentation on theme: "Latest Perspectives in PAD: How to Improve Outcomes"— Presentation transcript:

1 Latest Perspectives in PAD: How to Improve Outcomes

2 PAD: A Global Burden

3 PAD: A Generalized Process

4 PAD: Definitions

5 Risk Factors for PAD

6 Diagnosis: Ankle Brachial Index

7 CONTENT NO LONGER AVAILABLE
Reproduced with permission. AHA website.

8 PAD: Treatment

9 AHA/ACC Guidelines: Antiplatelet Agents

10 EUCLID: Primary Efficacy Endpoint

11 Latest Perspectives in PAD: How to Improve Outcomes?

12 COMPASS: CAD and PAD Groups

13 COMPASS: PAD Subgroup

14 COMPASS: PAD Subgroup (cont)

15 COMPASS: Incidence of Death Before and After MALE
CONTENT NO LONGER AVAILABLE doi: /j.jacc [Epub ahead of print] Rate are /100 pt-years Reprinted from J Am Coll Cardiol, pii: S (18) , Anand SS, Caron F, Eikelboom JW, et al, Major adverse limb events in lower extremity peripheral artery disease: COMPASS trial, Copyright 2018, with permission from Elsevier.

16 COMPASS: Incidence of Amputation Before and After MALE
CONTENT NO LONGER AVAILABLE doi: /j.jacc [Epub ahead of print] Reprinted from J Am Coll Cardiol, pii: S (18) , Anand SS, Caron F, Eikelboom JW, et al, Major adverse limb events in lower extremity peripheral artery disease: COMPASS trial, Copyright 2018, with permission from Elsevier.

17 COMPASS: Prognosis After MALE by Treatment Group

18 COMPASS: Patients With MALE Index Event
CONTENT NO LONGER AVAILABLE doi: /j.jacc Cox proportional hazards models with the MALE index event modelled as a time-dependent covariate *considering only those outcomes that did not occur on the same day as the index MALE Reprinted from J Am Coll Cardiol, pii: S (18) , Anand SS, Caron F, Eikelboom JW, et al, Major adverse limb events in lower extremity peripheral artery disease: COMPASS trial, Copyright 2018, with permission from Elsevier.

19 VOYAGER PAD: Study Design

20 Latest Perspectives in PAD: How to Improve Outcomes

21 Overview

22 PAD: A Polyvascular Disease

23 PAD: Increased Risk for MACE

24 AHA/ACC Guidelines: Antiplatelet Agents

25 PLATO and PEGASUS: PAD Subanalysis

26 EUCLID: Primary Efficacy Endpoint

27 Anticoagulation in PAD: WAVE

28 Latest Perspectives in PAD: How to Improve Outcomes

29 Lower Extremity Artery Disease: "LEAD"

30 ESC Guidelines

31 Measuring ABI

32 Therapeutic Approach to PAD

33 Limitations of Treatment

34 ESC Guidelines: Antiplatelet Therapy

35 COMPASS

36 Summary

37 Summary (cont)

38 Abbreviations

39 Abbreviations (cont)


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