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Outcome of Septal Myectomy in Patients With Fabry's Disease

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Presentation on theme: "Outcome of Septal Myectomy in Patients With Fabry's Disease"— Presentation transcript:

1 Outcome of Septal Myectomy in Patients With Fabry's Disease
Meghana R. Kunkala, MD, Marie Christine Aubry, MD, Steve R. Ommen, MD, Bernard J. Gersh, MB, ChB, Hartzell V. Schaff, MD  The Annals of Thoracic Surgery  Volume 95, Issue 1, Pages (January 2013) DOI: /j.athoracsur Copyright © 2013 The Society of Thoracic Surgeons Terms and Conditions

2 Fig 1 Patient 1. (A, B) Preoperative echocardiograms demonstrating systolic anterior motion and hypertrophy of the left ventricle. (C, D) Echocardiograms after patient was weaned from bypass demonstrating myectomy changes and resolution of systolic anterior motion. The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2013 The Society of Thoracic Surgeons Terms and Conditions

3 Fig 2 Patient 1. (A) Intraoperative photograph of excised specimen demonstrating endocardial scar. (B) High-power photomicrograph from a subaortic resection specimen shows diffusely enlarged myocytes with prominent central vacuolization of the cytoplasm (hematoxylin-eosin, original magnification ×400). The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2013 The Society of Thoracic Surgeons Terms and Conditions

4 Fig 3 Patient 2. (A, B) Preoperative cardiac magnetic resonance image demonstrating extent of hypertrophy of the ventricle. (C) Transmission electron microscopy shows that the sarcoplasmic vacuoles contain myeloid figures (arrow) characterized by concentric laminated electron-dense material (original magnification ×11,000). The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2013 The Society of Thoracic Surgeons Terms and Conditions

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