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BRMS1 Expression in Surgically Resected Lung Adenocarcinoma Predicts Future Metastases and Is Associated with a Poor Prognosis  Peter R. Bucciarelli,

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Presentation on theme: "BRMS1 Expression in Surgically Resected Lung Adenocarcinoma Predicts Future Metastases and Is Associated with a Poor Prognosis  Peter R. Bucciarelli,"— Presentation transcript:

1 BRMS1 Expression in Surgically Resected Lung Adenocarcinoma Predicts Future Metastases and Is Associated with a Poor Prognosis  Peter R. Bucciarelli, MD, Kay See Tan, PhD, Neel P. Chudgar, MD, Whitney Brandt, MD, Joseph Montecalvo, MD, Takashi Eguchi, MD, PhD, Yuan Liu, MD, PhD, Rania Aly, MD, William D. Travis, MD, Prasad S. Adusumilli, MD, David R. Jones, MD  Journal of Thoracic Oncology  Volume 13, Issue 1, Pages (January 2018) DOI: /j.jtho Copyright © 2017 International Association for the Study of Lung Cancer Terms and Conditions

2 Figure 1 Immunohistochemical analysis of breast cancer metastasis suppressor 1 (BRMS1). Representative photomicrographs show different expression scores of BRMS1 immunostaining in lung adenocarcinoma. (Original magnification: ×10 [top row] and ×40 [bottom row]. Journal of Thoracic Oncology  , 73-84DOI: ( /j.jtho ) Copyright © 2017 International Association for the Study of Lung Cancer Terms and Conditions

3 Figure 2 Low intratumoral breast cancer metastasis suppressor 1 (BRMS1) expression is associated with reduced overall survival (A) and disease-free survival (B). Journal of Thoracic Oncology  , 73-84DOI: ( /j.jtho ) Copyright © 2017 International Association for the Study of Lung Cancer Terms and Conditions

4 Figure 3 The disease-free survival (DFS) nomogram provides a graphic approach to calculate 5-year DFS after resection on the basis of a patient’s combination of clinicopathologic covariates. First, locate the patient’s age and draw a line straight up to the points axis to derive the score associated with an age. Repeat for the other covariates on the nomogram. Add the scores for each covariate to determine the total score. Draw a vertical line from the total points axis to the 5-year DFS axis to obtain the predicted probability. PN, pneumonectomy; Seg, segment; BRMS1, breast cancer metastasis suppressor 1; OS, overall survival; LPD, lepidic; ACI, acinar; PAP, papillary; SOL, solid; MIP, micropapillary. Journal of Thoracic Oncology  , 73-84DOI: ( /j.jtho ) Copyright © 2017 International Association for the Study of Lung Cancer Terms and Conditions

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