1. Prediction and Pathogenesis in Type 1 Diabetes
Anette-G. Ziegler, Gerald T. Nepom 
Immunity 
Volume 32, Issue 4, Pages (April 2010)
DOI: /j.immuni
Copyright © 2010 Elsevier Inc. Terms and Conditions

2. Figure 1
Individual Stratification for Diabetes Risk Reflects Stages of Disease Progression
The following abbreviations are used: GAD, glutamic acid decarboxylase; IA-2, islet-associated autoantibody 2; ZnT8, zinc transporter 8; IVGTT, intravenous glucose tolerance test; OGTT, oral glucose tolerance test; and HbA1c, hemoglobin A1c.
Immunity  , DOI: ( /j.immuni )
Copyright © 2010 Elsevier Inc. Terms and Conditions

3. Figure 2
Type 1 Diabetes Risk Stratification by Islet Autoantibody Properties
Increase in T1D risk is associated with progression of islet autoantibodies from single to multiple autoantibodies. Characteristics of the initial antibody response can help predict disease progression. The following abbreviations are used: IAA, insulin autoantibodies; GAD65, glutamic acid decarboxylase 65; IA-2, islet-associated autoantibody 2; and ZnT8, zinc transporter 8.
Immunity  , DOI: ( /j.immuni )
Copyright © 2010 Elsevier Inc. Terms and Conditions

4. Figure 3 Incidence of Islet Autoantibodies
Cases with at least one Ab of IAA, GADA, IA2A, or ZnT8A per year, expressed as a percentage of children with a family history of diabetes ascertained in the BABYDIAB study population; abbreviations as in legend to Figure 2. Two waves of islet autoimmunity with an increased incidence at ∼1 year of age (“neonate” autoimmunity) and at around puberty are observed with distinct characteristics.
Immunity  , DOI: ( /j.immuni )
Copyright © 2010 Elsevier Inc. Terms and Conditions