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p62 in Cancer: Signaling Adaptor Beyond Autophagy

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Presentation on theme: "p62 in Cancer: Signaling Adaptor Beyond Autophagy"— Presentation transcript:

1 p62 in Cancer: Signaling Adaptor Beyond Autophagy
Jorge Moscat, Michael Karin, Maria T. Diaz-Meco  Cell  Volume 167, Issue 3, Pages (October 2016) DOI: /j.cell Copyright © 2016 Elsevier Inc. Terms and Conditions

2 Figure 1 p62 Signaling Functions in the Tumor Epithelium and Stroma
(A) Structural domain organization of p62, binding partners, and signaling functions. p62 has a PB1 domain, a ZZ-type zinc finger domain, a TRAF6-binding (TB) domain, an LC3-interacting region (LIR), a Keap1-interacting region, and a ubiquitin-associated domain (UBA). (B) Central role of p62 accumulation in the tumor epithelium during cancer initiation through detoxification and mTORC1 activation. (C) Role of p62 downregulation in the tumor stroma through the inhibition of mTORC1 in metabolic reprogramming and inflammation Cell  , DOI: ( /j.cell ) Copyright © 2016 Elsevier Inc. Terms and Conditions

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