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Volume 80, Issue 4, Pages (August 2011)

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Presentation on theme: "Volume 80, Issue 4, Pages (August 2011)"— Presentation transcript:

1 Volume 80, Issue 4, Pages 405-414 (August 2011)
Urinary neutrophil gelatinase-associated lipocalin distinguishes pre-renal from intrinsic renal failure and predicts outcomes  Eugenia Singer, Antje Elger, Saban Elitok, Ralph Kettritz, Thomas L. Nickolas, Jonathan Barasch, Friedrich C. Luft, Kai M. Schmidt-Ott  Kidney International  Volume 80, Issue 4, Pages (August 2011) DOI: /ki Copyright © 2011 International Society of Nephrology Terms and Conditions

2 Figure 1 Study flow diagram. AKI, acute kidney injury.
Kidney International  , DOI: ( /ki ) Copyright © 2011 International Society of Nephrology Terms and Conditions

3 Figure 2 Box plots of biomarker levels in differential diagnosis of acute kidney injury (AKI) and prediction of outcomes. Biomarker levels are presented on a log 10 scale. Boxes indicate median, lower, and upper quartiles. Lower and upper whiskers represent data within 1.5 interquartile ranges of the lower quartile and within 1.5 interquartile ranges of the upper quartile, respectively, of log 10-transformed biomarker levels. Circles represent outliers. NGAL, neutrophil gelatinase-associated lipocalin. *P<0.05, **P<0.01, ***P<0.001. Kidney International  , DOI: ( /ki ) Copyright © 2011 International Society of Nephrology Terms and Conditions

4 Figure 3 Urinary neutrophil gelatinase-associated lipocalin (NGAL) levels and outcomes. Patients were stratified by NGAL level. Percentages of the subgroups that experience aspects of the composite outcome are shown. P for trend is significant for composite and individual clinical outcomes. RIFLE: Risk, Injury, Failure, Loss of function, End stage renal disease. Kidney International  , DOI: ( /ki ) Copyright © 2011 International Society of Nephrology Terms and Conditions

5 Figure 4 Sub-stratification of RIFLE severity classes by neutrophil gelatinase-associated lipocalin (NGAL). Patients were stratified by RIFLE severity class (R, I, F) and by NGAL level (cutoff 104μg/l). Percentages of in-hospital mortality, in-hospital dialysis initiation, or a composite outcome are plotted by RIFLE class and NGAL levels. *P<0.05 versus NGAL ≤104μg/l. RIFLE: Risk, Injury, Failure, Loss of function, End stage renal disease. Kidney International  , DOI: ( /ki ) Copyright © 2011 International Society of Nephrology Terms and Conditions


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