1. REFMAC Garib N Murshudov, Alexei A Vagin, Andrey Lebedev James Foadi, Fei Long

2. Version 5.3
From SMILE string to dictionary (LIBCHECK): Now coot uses it
Segment id is now used
Automatic adjustment for weights
Improved bond order extraction from coordinates (more chemical assumptions)
External restraints
Simple xml files for communication

3. For version 6.0 Auto twin refinement Occupancy refinement
Restraints to external similar molecules
Restraints fro secondary structures?
Better NCS restraints (local similarity)
And some other things

4. Beyond the next release
QM optimisation of ligands
QM optimised templates
Bootstrap for bias removal and resolution extension
Resolution extension for map calculations
And many other things

5. Low resolution
B value
Unmerged