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A single-center experience of 1500 lung transplant patients

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Presentation on theme: "A single-center experience of 1500 lung transplant patients"— Presentation transcript:

1 A single-center experience of 1500 lung transplant patients
Keki R. Balsara, MD, Alexander S. Krupnick, MD, Jennifer M. Bell, RN, Ali Khiabani, MD, Masina Scavuzzo, RN, BSN, Ramsey Hachem, MD, Elbert Trulock, MD, Chad Witt, MD, Derek E. Byers, MD, PhD, Roger Yusen, MD, Bryan Meyers, MD, MPH, Benjamin Kozower, MD, G. Alexander Patterson, MD, Varun Puri, MD, MSCI, Daniel Kreisel, MD, PhD  The Journal of Thoracic and Cardiovascular Surgery  Volume 156, Issue 2, Pages e3 (August 2018) DOI: /j.jtcvs Copyright © 2018 The American Association for Thoracic Surgery Terms and Conditions

2 Figure 1 Overall survival of all 1500 transplanted patients as a function of time. Ninety-five percent confidence limits are represented by the thin lines. The Journal of Thoracic and Cardiovascular Surgery  , e3DOI: ( /j.jtcvs ) Copyright © 2018 The American Association for Thoracic Surgery Terms and Conditions

3 Figure 2 Overall survival stratified by diagnosis groups, including cystic fibrosis (CF), chronic obstructive pulmonary disease (COPD), pulmonary fibrosis (IPF), and other (including pulmonary hypertension, α-1 anti-trypsin deficiency, and lymphangioleiomyomastosis). There is a statistically significant difference in survival among the groups (P < .007). Ninety-five percent confidence limits are represented by the thin lines. See Table E1 for survival and 95% confidence intervals separated by disease process. The Journal of Thoracic and Cardiovascular Surgery  , e3DOI: ( /j.jtcvs ) Copyright © 2018 The American Association for Thoracic Surgery Terms and Conditions

4 Figure 3 Overall survival stratified by time groups. Early transplant (group 1) had decreased short- and long-term survival when compared with late transplant (group 2; P < .0001). Ninety-five percent confidence limits are represented by the thin lines. The Journal of Thoracic and Cardiovascular Surgery  , e3DOI: ( /j.jtcvs ) Copyright © 2018 The American Association for Thoracic Surgery Terms and Conditions

5 Figure 4 A, Overall survival stratified by diagnosis groups in early transplant patients. Ninety-five percent confidence limits are represented by the thin lines. See Table E2 for survival and 95% confidence intervals separated by disease process. B, Overall survival stratified by diagnosis groups in late transplant patients. Ninety-five percent 95% confidence limits are represented by the thin lines. See Table E3 for survival and 95% confidence intervals separated by disease process. CF, Cystic fibrosis; COPD, chronic obstructive pulmonary disease; IPF, interstitial pulmonary fibrosis. The Journal of Thoracic and Cardiovascular Surgery  , e3DOI: ( /j.jtcvs ) Copyright © 2018 The American Association for Thoracic Surgery Terms and Conditions

6 Figure 5 A, Overall time to development of bronchiolitis obliterans syndrome (BOS). Ninety-five percent confidence limits are represented by the thin lines. B, Overall time to development of BOS, stratified by time groups. Early transplant (group 1) had a statistically significant reduced freedom from BOS at all time points compared to late transplant (group 2; P < .0001). Ninety-five percent confidence limits are represented by the thin lines. The Journal of Thoracic and Cardiovascular Surgery  , e3DOI: ( /j.jtcvs ) Copyright © 2018 The American Association for Thoracic Surgery Terms and Conditions

7 Figure E1 Freedom from bronchiolitis obliterans syndrome (BOS) for patients with chronic obstructive pulmonary disease, separated by group. Early transplant (pre-las) and late transplant (post-las) 95% confidence limits are represented by the thin lines. COPD, Chronic obstructive pulmonary disease. The Journal of Thoracic and Cardiovascular Surgery  , e3DOI: ( /j.jtcvs ) Copyright © 2018 The American Association for Thoracic Surgery Terms and Conditions

8 Figure E2 Freedom from bronchiolitis obliterans syndrome (BOS) for patients with cystic fibrosis, separated by group. Early transplant (pre-las) and late transplant (post-las) 95% confidence limits are represented by the thin lines. CF, Cystic fibrosis. The Journal of Thoracic and Cardiovascular Surgery  , e3DOI: ( /j.jtcvs ) Copyright © 2018 The American Association for Thoracic Surgery Terms and Conditions

9 Figure E3 Freedom from bronchiolitis obliterans syndrome (BOS) for patients with interstitial pulmonary fibrosis, separated by group. Early transplant (pre-las) and late transplant (post-las) 95% confidence limits are represented by the thin lines. PF, Pulmonary fibrosis. The Journal of Thoracic and Cardiovascular Surgery  , e3DOI: ( /j.jtcvs ) Copyright © 2018 The American Association for Thoracic Surgery Terms and Conditions

10 Overall survival of all patients separated by disease process.
The Journal of Thoracic and Cardiovascular Surgery  , e3DOI: ( /j.jtcvs ) Copyright © 2018 The American Association for Thoracic Surgery Terms and Conditions

11 Video 1 Video recording highlighting the most salient features of this manuscript using slides from The American Association for Thoracic Surgery 2017 oral presentation. Information highlighted includes overall survival, disease-specific survival, and incidence of primary graft dysfunction and bronchiolitis obliterans syndrome across all groups examined. Video available at: The Journal of Thoracic and Cardiovascular Surgery  , e3DOI: ( /j.jtcvs ) Copyright © 2018 The American Association for Thoracic Surgery Terms and Conditions

12 The Journal of Thoracic and Cardiovascular Surgery 2018 156, 894-905
The Journal of Thoracic and Cardiovascular Surgery  , e3DOI: ( /j.jtcvs ) Copyright © 2018 The American Association for Thoracic Surgery Terms and Conditions

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