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SIP-ing the Elixir of Youth

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Presentation on theme: "SIP-ing the Elixir of Youth"— Presentation transcript:

1 SIP-ing the Elixir of Youth
William Mair, Kristan K. Steffen, Andrew Dillin  Cell  Volume 146, Issue 6, Pages (September 2011) DOI: /j.cell Copyright © 2011 Elsevier Inc. Terms and Conditions

2 Figure 1 The Deactylation Life Span Clock
Deacetylation of the yeast AMPK subunit Sip2 with time acts as an intrinsic aging clock, which drives cellular aging by a mechanism that is distinct from the effects of dietary restriction. As yeast cells age, Sip2 becomes deacetylated, removing its repression of the AMPK homolog Snf1 and inducing cellular aging via Sch9 phosphorylation. The life span clock can be wound backward via Sip2 acetylation mimics or by inactivating the deacetylase Rpd3, promoting longevity. These findings describe a novel level of AMPK regulation with age and pose new questions about the links between energy homeostasis and longevity and the potential of AMPK as a target to treat age-related disease. Cell  , DOI: ( /j.cell ) Copyright © 2011 Elsevier Inc. Terms and Conditions

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