1. Lactate Wreaks Havoc on Tumor-Infiltrating T and NK Cells
Kristen E.N. Scott, John L. Cleveland 
Cell Metabolism 
Volume 24, Issue 5, Pages (November 2016)
DOI: /j.cmet
Copyright © 2016 Elsevier Inc. Terms and Conditions

2. Figure 1 Lactate Lowers the Boom on Immune Surveillance
Left half: highly glycolytic tumor cells express high levels of LDHA and efflux lactic acid (orange squares) acidifying (yellow) the tumor milieu and compromising activation of CD8+ T and NK cells and their competition for nutrients, such as glucose (blue squares) or amino acids (e.g., arginine, green squares). Right half: tumor cells with low levels of LDHA are poor competitors for nutrients in the tumor microenvironment, allowing effective recruitment and activation of immune cells, their release of IFNγ (black dots) that further drives immune cell activation, and tumor cell killing.
Cell Metabolism  , DOI: ( /j.cmet )
Copyright © 2016 Elsevier Inc. Terms and Conditions