1. ANTIFUNGAL THERAPY

2. CASE PRESENTAION HISTORY Clinical finding AGE : 62 SEX : Female
Chief complain : changing the dentures.
No symptom

3. Diagnosis
Denture sore mouth

4. Antifungal drugs Polyene Anti fungals Azole Nystatin Oral - topical
Coated tab: unit Sus Drop: unit/ml
Topical
Oint: unit/g
Vaginal
Tab: unit
Amphotericin b
Systemic
INJ: 50 mg
Azole
Clotrimazole
Cream 1% - Solution 1% (20ml)
Miconazole Nitrate
Cream 2%
Fluconazole
Tab: 50 , 100 , 150 mg Cap: 50 , 100 , 150 mg
Itraconazole
Cap: 100 mg
Ketoconazole
Tab : 200mg Cream : 2% Lotion : 2%

5. Prescription Nystatin (Mycostatin, Nilstat) oral suspension
100,000 units/mL
Take 2 to 5 mL 4 times a day. Rinse for 2 minutes,
and swallow.
Nystatin suspension has a high sugar
content; therefore, good oral hygiene should be
reinforced.
A few drops of nystatin oral suspension
can be added to the water used for soaking
acrylic prostheses.

6. Alternative treatment-1
Nystatin vaginal suppositories 100,000 U
Disp: 40 suppositories
Sig: Let 1 suppository dissolve in the mouth 4 times a day.
Do not rinse for 30 minutes.

7. Alternative treatment-2
Clotrimazole troches 10 mg
Disp: 70 troches
Sig: Let 1 troche dissolve in the mouth 5 times a day.
If concern is expressed about the sugar content of nystatin and clotrimazole troches, vaginal tablets may be substituted.

8. Alternative treatment-3
Ketoconazole (Nizoral) cream 2%
Disp: 15-g tube
Sig: Apply thin coat to inner surface of denture and affected areas after each meal.

9. Alternative treatment-4
Clotrimazole vaginal
cream 1% (OTC)
Disp: 1 tube
Sig: Apply small dab to tissue side of denture or to infected oral mucosa 4 times a day.

10. Systemic treatment Ketoconazole (Nizoral) tablets 200 mg
Disp: 20 tablets
Sig: Take 1 tablet daily with a meal or with orange juice
Fluconazole (Diflucan) tablets 100 mg
Sig: Take 2 tablets stat, then 1 tablet daily