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Changes in the effect of propofol in response to altered plasma protein binding during normothermic cardiopulmonary bypass  E Takizawa, H Hiraoka, D Takizawa,

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Presentation on theme: "Changes in the effect of propofol in response to altered plasma protein binding during normothermic cardiopulmonary bypass  E Takizawa, H Hiraoka, D Takizawa,"— Presentation transcript:

1 Changes in the effect of propofol in response to altered plasma protein binding during normothermic cardiopulmonary bypass  E Takizawa, H Hiraoka, D Takizawa, F Goto  British Journal of Anaesthesia  Volume 96, Issue 2, Pages (February 2006) DOI: /bja/aei293 Copyright © 2006 British Journal of Anaesthesia Terms and Conditions

2 Fig 1 Total (open symbols) and unbound (closed symbols) propofol concentration in blood during constant-rate infusion of 4 (circles) and 6 (squares) mg kg−1 h−1 propofol in patients undergoing cardiac surgery with CPB (mean±sd). The horizontal axis indicates the time points studied: T1, just before skin incision (range, 45–65 min after the infusion of propofol); T2, before administration of heparin; T3 and T4, corresponding to 30 and 60 min after the start of CPB. **P<0.01, significant differences compared with the value at T1 or between groups. British Journal of Anaesthesia  , DOI: ( /bja/aei293) Copyright © 2006 British Journal of Anaesthesia Terms and Conditions

3 Fig 2 Change in the unbound fraction of propofol in blood during constant-rate infusion of 4 (Group P-4, circles) and 6 (Group P-6, squares) mg kg−1 h−1 propofol in patients undergoing cardiac surgery with CPB (mean±sd). **P<0.01, a significant difference compared with the value at T1. British Journal of Anaesthesia  , DOI: ( /bja/aei293) Copyright © 2006 British Journal of Anaesthesia Terms and Conditions

4 Fig 3 Apparent erythrocyte/blood partition coefficient (KRBC/Blood) during constant-rate infusion of 4 (Group P-4, circles) and 6 (Group P-6, squares) mg kg−1 h−1 propofol in patients undergoing cardiac surgery with CPB (mean±sd). KRBC/Blood represents the ratio of propofol concentration in erythrocytes to that in the blood. **P<0.01, a significant difference compared with the value at T1. British Journal of Anaesthesia  , DOI: ( /bja/aei293) Copyright © 2006 British Journal of Anaesthesia Terms and Conditions

5 Fig 4 BIS (open symbols) and BSR (closed symbols) during constant-rate infusion of 4 (circles) and 6 (squares) mg kg−1 h−1 propofol in patients undergoing cardiac surgery with CPB (mean±sd). *P<0.05, **P<0.01, significant differences compared with the value at T1. British Journal of Anaesthesia  , DOI: ( /bja/aei293) Copyright © 2006 British Journal of Anaesthesia Terms and Conditions

6 Fig 5 (a) The relationship between total propofol concentration in blood during constant-rate infusion of 4 (circles) and 6 (squares) mg kg−1 h−1 propofol and the BIS values with a regression slope (r2=0.15, P<0.001). (b) The relationship between unbound propofol concentration in blood and the BIS values with a regression slope (r2=0.19, P<0.001). British Journal of Anaesthesia  , DOI: ( /bja/aei293) Copyright © 2006 British Journal of Anaesthesia Terms and Conditions

7 Fig 6 (a) The relationship between total propofol concentration in blood during constant-rate infusion of 4 (circles) and 6 (squares) mg kg−1 h−1 propofol and the BSR with a regression slope (r2=0.27, P<0.001). (b) The relationship between unbound propofol concentration in blood and the BSR with a regression slope (r2=0.56, P<0.001). British Journal of Anaesthesia  , DOI: ( /bja/aei293) Copyright © 2006 British Journal of Anaesthesia Terms and Conditions

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