1. Unraveling Cell-Cycle Dynamics in Cancer
Sandip Kar 
Cell Systems 
Volume 2, Issue 1, Pages 8-10 (January 2016)
DOI: /j.cels
Copyright © 2016 Elsevier Inc. Terms and Conditions

2. Figure 1
Schematic Representation of Dynamical Features of the All-or-None G1-S Transition
(A) The antagonistic relationship between Cdk2:Cyclins and p27Kip1 is essential for a switch-like G1-S transition. The orange line signifies stable steady states and the dash line unstable steady states.
(B) Cdk2:CyclinE1, and not Cdk2:CyclinA, is responsible for the timing of the G1-S transition.
(C) In the absence of Cdk2:CyclinE1, Cdk2:CyclinA can take over the job of keeping timing of the G1-S transition.
(D) Levels of Emi1 protein can control the irreversibility of the G1-S transition.
Cell Systems 2016 2, 8-10DOI: ( /j.cels )
Copyright © 2016 Elsevier Inc. Terms and Conditions