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Effects of Dialysate Acidification With Citrate Versus Acetate on Cell Damage, Uremic Toxin Levels, and Inflammation in Patients Receiving Maintenance Hemodialysis Su Woong Jung, MD, Da Rae Kim, MD, Kyung Sook Cho, PhD, Jung-Woo Seo, PhD, Haena Moon, MS, Eun Ji Park, MD, Jin Sug Kim, MD, Tae Won Lee, MD, PhD, Chun Gyoo Ihm, MD, PhD, Da Wun Jeong, MD, Ki-Pyo Kim, MD, Yu Ho Lee, MD, Ju-Young Moon, MD, PhD, Yang Gyun Kim, MD, PhD, Sang-Ho Lee, MD, PhD, Kyung Hwan Jeong, MD, PhD American Journal of Kidney Diseases Volume 73, Issue 3, Pages (March 2019) DOI: /j.ajkd Copyright © 2018 National Kidney Foundation, Inc. Terms and Conditions
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Figure 1 Effects of dialysates with citrate and acetate additives on cell-free mtDNA and indoxyl sulfate: (A) intradialytic changes in cell-free mtDNA, (B) changes in cell-free mtDNA over 13 weeks, (C) intradialytic changes in indoxyl sulfate, and (D) changes in indoxyl sulfate over 13 weeks. Bars show means and error bars denote standard error of the mean. A total of 59 patients were evaluated for the analysis of indoxyl sulfate because of missing values. A linear mixed model was used for comparison between the 2 dialysates, whereas paired t tests or Wilcoxon signed rank tests were used for comparison within each dialysate. *P<0.05, ∗∗P<0.01, ***P< Abbreviations: mtDNA, mitochondrial DNA; post, postdialysis concentration; pre, predialysis concentration. American Journal of Kidney Diseases , DOI: ( /j.ajkd ) Copyright © 2018 National Kidney Foundation, Inc. Terms and Conditions
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