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Volume 12, Issue 8, Pages (August 2011)

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Presentation on theme: "Volume 12, Issue 8, Pages (August 2011)"— Presentation transcript:

1 Volume 12, Issue 8, Pages 743-752 (August 2011)
Effects of zoledronic acid versus clodronic acid on skeletal morbidity in patients with newly diagnosed multiple myeloma (MRC Myeloma IX): secondary outcomes from a randomised controlled trial  Prof Gareth J Morgan, MD, Prof J Anthony Child, MD, Prof Walter M Gregory, PhD, Alex J Szubert, MSc, Kim Cocks, MSc, Sue E Bell, DPhil, Nuria Navarro-Coy, MPhil, Mark T Drayson, MD, Roger G Owen, MD, Sylvia Feyler, MD, A John Ashcroft, MD, Fiona M Ross, DPhil, Jennifer Byrne, MD, Huw Roddie, MD, Claudius Rudin, MD, Gordon Cook, MD, Prof Graham H Jackson, MD, Ping Wu, MSc, Faith E Davies, MD  The Lancet Oncology  Volume 12, Issue 8, Pages (August 2011) DOI: /S (11) Copyright © 2011 Elsevier Ltd Terms and Conditions

2 Figure 1 Trial profile The complete trial protocol is provided in Morgan and colleagues.12 CVAD=cyclophosphamide, vincristine, doxorubicin, and dexamethasone. CTD=cyclophosphamide, thalidomide, and dexamethasone. MP=melphalan and prednisolone. CTDa=attenuated CTD. The Lancet Oncology  , DOI: ( /S (11) ) Copyright © 2011 Elsevier Ltd Terms and Conditions

3 Figure 2 Time to first skeletal-related event overall (A), in patients with bone lesions at baseline (B), and in patients without bone lesions at baseline (C) HR=hazard ratio. *Cox p value. The Lancet Oncology  , DOI: ( /S (11) ) Copyright © 2011 Elsevier Ltd Terms and Conditions

4 Figure 3 Proportion of patients with an on-study skeletal-related event overall (A), with bone lesions at baseline (B), and without bone lesions at baseline (C) The Lancet Oncology  , DOI: ( /S (11) ) Copyright © 2011 Elsevier Ltd Terms and Conditions


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