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Reversible pulmonary trunk banding III: Assessment of myocardial adaptive mechanisms—contribution of cell proliferation  Maria C.D. Abduch, DVM, PhD,

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Presentation on theme: "Reversible pulmonary trunk banding III: Assessment of myocardial adaptive mechanisms—contribution of cell proliferation  Maria C.D. Abduch, DVM, PhD,"— Presentation transcript:

1 Reversible pulmonary trunk banding III: Assessment of myocardial adaptive mechanisms—contribution of cell proliferation  Maria C.D. Abduch, DVM, PhD, Renato S. Assad, MD, PhD, Miguel Q. Rodriguez, MD, PhD, Acrisio S. Valente, MD, José L. Andrade, MD, PhD, Léa M.M. Demarchi, MD, PhD, Miguel B. Marcial, MD, PhD, Vera D. Aiello, MD, PhD  The Journal of Thoracic and Cardiovascular Surgery  Volume 133, Issue 6, Pages (June 2007) DOI: /j.jtcvs Copyright © 2007 The American Association for Thoracic Surgery Terms and Conditions

2 Figure 1 RV estimated mass (g) during training days. RV, Right ventricle; C, control group; CS, continuous stimulated group; IS, intermittent stimulated group. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /j.jtcvs ) Copyright © 2007 The American Association for Thoracic Surgery Terms and Conditions

3 Figure 2 Bidimensional echocardiogram at baseline (A) and after 5 days of training (B) in a CS group goat. RV, right ventricle; LV, left ventricle; PE, pericardial effusion. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /j.jtcvs ) Copyright © 2007 The American Association for Thoracic Surgery Terms and Conditions

4 Figure 3 Photomicrographs of the RV myocardium showing Ki-67 immunostaining. A, Arrows indicate 2 labeled cardiomyocyte nuclei. B, Numerous positive nuclei from interstitial and vessel cells. Objective: 40×; counterstaining with Harry’s hematoxylin. RV, Right ventricle. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /j.jtcvs ) Copyright © 2007 The American Association for Thoracic Surgery Terms and Conditions

5 Figure 4 Mean and SE values of: (A) cardiomyocytes Ki-67-positive index (number of positive cells/2000 cardiomyocytes expressed as a percentage); (B) interstitial/vessel cells Ki-67-positive index (number of positive cells/2000 expressed as a percentage). RV, right ventricle; LV, left ventricle; RVS, right half of ventricular septum; LVS, left half of ventricular septum. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /j.jtcvs ) Copyright © 2007 The American Association for Thoracic Surgery Terms and Conditions


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