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Percutaneous venovenous Perfusion-Induced systemic hyperthermia for lung cancer: a phase I safety study  Joseph B Zwischenberger, MD, Roger A Vertrees,

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Presentation on theme: "Percutaneous venovenous Perfusion-Induced systemic hyperthermia for lung cancer: a phase I safety study  Joseph B Zwischenberger, MD, Roger A Vertrees,"— Presentation transcript:

1 Percutaneous venovenous Perfusion-Induced systemic hyperthermia for lung cancer: a phase I safety study  Joseph B Zwischenberger, MD, Roger A Vertrees, PhD, Eric A Bedell, MD, Christopher K McQuitty, MD, Jill M Chernin, RN, Lee C Woodson, MD, PhD  The Annals of Thoracic Surgery  Volume 77, Issue 6, Pages (June 2004) DOI: /j.athoracsur

2 Fig 1 Schematic diagram of the venovenous perfusion-induced systemic hyperthermia circuit. The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur )

3 Fig 2 Time course to the target average (Ave) core temperature during venovenous perfusion-induced systemic hyperthermia. The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur )

4 Fig 3 Time course of average temperature change by measured site during venovenous perfusion-induced systemic hyperthermia. (L = left; R = right). The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur )

5 Fig 4 The dynamics of heat exchange between the heat exchanger water bath, the extracorporeal circuit blood temperature, and the core body temperature. The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur )

6 Fig 5 Survival following original diagnosis (DX) with stage IV NSC lung cancer (VV-PISH+, 504 ± 102 days versus control, 171 ± 194 days, p < 0.05). Median survival was VV-PISH, 450 days versus control, 96 days. (NSC = non-small cell; VV-PISH = venovenous perfusion-induced systemic hyperthermia.) The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur )


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