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Joshua E. Rosen, BASc, Michelle C

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1 Lobectomy versus stereotactic body radiotherapy in healthy patients with stage I lung cancer 
Joshua E. Rosen, BASc, Michelle C. Salazar, MD, Zuoheng Wang, PhD, James B. Yu, MD, MHS, Roy H. Decker, MD, PhD, Anthony W. Kim, MD, Frank C. Detterbeck, MD, Daniel J. Boffa, MD  The Journal of Thoracic and Cardiovascular Surgery  Volume 152, Issue 1, Pages e9 (July 2016) DOI: /j.jtcvs Copyright © 2016 The American Association for Thoracic Surgery Terms and Conditions

2 Figure 1 Health-based patient selection process. NSCLC, Non–small cell lung cancer; SBRT, stereotactic body radiation therapy. The Journal of Thoracic and Cardiovascular Surgery  , e9DOI: ( /j.jtcvs ) Copyright © 2016 The American Association for Thoracic Surgery Terms and Conditions

3 Figure 2 Survival curves (from diagnosis) of healthy patients with clinical stage I NSCLC derived by the Kaplan–Meier method. Propensity-matched “healthy” patients with lobectomy and SBRT (A) and propensity-matched patients with lobectomy and patients with SBRT (B) who were recommended to have surgery but refused. SBRT, Stereotactic body radiation therapy; Tx, treatment. The Journal of Thoracic and Cardiovascular Surgery  , e9DOI: ( /j.jtcvs ) Copyright © 2016 The American Association for Thoracic Surgery Terms and Conditions

4 Figure E1 Full consort diagram detailing cohort selection. *NSCLC histology codes included 8010, , 8020, 8046, , , , 8143, 8147, 8260, 8310, 8430, , 8490, 8560, and PUF, Participant user file; NSCLC, non–small cell lung cancer; SBRT, stereotactic body radiation therapy. The Journal of Thoracic and Cardiovascular Surgery  , e9DOI: ( /j.jtcvs ) Copyright © 2016 The American Association for Thoracic Surgery Terms and Conditions

5 Figure E2 Kaplan–Meier survival analysis of the 13,652 patients who received lobectomy versus the 854 patients who received SBRT with a BED10 of at least 130 Gy. SBRT, Stereotactic body radiation therapy; Tx, treatment. The Journal of Thoracic and Cardiovascular Surgery  , e9DOI: ( /j.jtcvs ) Copyright © 2016 The American Association for Thoracic Surgery Terms and Conditions

6 Figure E3 Kaplan–Meier survival analysis of the unmatched 13,652 health patients with lobectomy versus the 1781 healthy patients with SBRT. SBRT, Stereotactic body radiation therapy; Tx, treatment. The Journal of Thoracic and Cardiovascular Surgery  , e9DOI: ( /j.jtcvs ) Copyright © 2016 The American Association for Thoracic Surgery Terms and Conditions

7 Figure E4 Kaplan–Meier survival analysis of the unmatched 29,032 patients with lobectomy versus the 235 patients with SBRT who were offered surgery but refused. SBRT, Stereotactic body radiation therapy; Tx, treatment. The Journal of Thoracic and Cardiovascular Surgery  , e9DOI: ( /j.jtcvs ) Copyright © 2016 The American Association for Thoracic Surgery Terms and Conditions

8 Overall survival of matched patients with stage I NSCLC treated with lobectomy or SBRT.
The Journal of Thoracic and Cardiovascular Surgery  , e9DOI: ( /j.jtcvs ) Copyright © 2016 The American Association for Thoracic Surgery Terms and Conditions

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