1. Inhibition of cyclooxygenase-2 (COX-2) by meloxicam decreases the incidence of ovarian hyperstimulation syndrome in a rat model 
Ramiro Quintana, M.D., Laura Kopcow, M.D., Guillermo Marconi, M.D., Edgardo Young, Ph.D., Carola Yovanovich, B.Sc., Dante A. Paz, Ph.D. 
Fertility and Sterility 
Volume 90, Issue 4, Pages (October 2008)
DOI: /j.fertnstert
Copyright © 2008 American Society for Reproductive Medicine Terms and Conditions

2. Figure 1
Right ovary weights of OHHS rats ± meloxicam. Control = saline treated. Mild = treated with 10 IU of PMSG and 10 IU of hCG 48 hours later. OHSS = treated with 10 IU of PMSG for 4 consecutive days and 30 IU hCG. OHSS + M = treated similarly as the OHSS group plus 2 μL (15 mg/mL) of meloxicam for 5 consecutive days. Data are presented as the mean ± SD (n = 10 rats). Superscript letters designate statistically significant differences (P≤.05). See text for abbreviations.
Fertility and Sterility  , DOI: ( /j.fertnstert )
Copyright © 2008 American Society for Reproductive Medicine Terms and Conditions

3. Figure 2
Number of luteinized follicles of OHHS rats ± meloxicam. Data are presented as the mean ± SD (n = 10 rats). Mild = treated with 10 IU of PMSG and 10 IU of hCG 48 hours later. OHSS = treated with 10 IU of PMSG for 4 consecutive days and 30 IU hCG. OHSS + M = treated similarly as the OHSS group plus 2 μL (15 mg/mL) of meloxicam for 5 consecutive days. Superscript letters designate statistically significant differences (P≤.05). See text for abbreviations.
Fertility and Sterility  , DOI: ( /j.fertnstert )
Copyright © 2008 American Society for Reproductive Medicine Terms and Conditions

4. Figure 3
Immunohistochemistry analysis of VEGF immunolocalization in the ovaries of OHHS rats ± meloxicam. (A) A representative ovarian section showing the immunolocalization of VEGF in a control rat (×100). (B) A representative ovarian section from a mild-treated rat (×200). (C) A representative ovarian section from an OHSS rat (×100). (D) A representative ovarian section from an OHSS plus meloxicam-treated rat (×100). (E) Densitometric analyses of VEGF immunoreactivity in the rat ovaries. Superscript letters designate statistically significant differences (P≤.05). See text for abbreviations.
Fertility and Sterility  , DOI: ( /j.fertnstert )
Copyright © 2008 American Society for Reproductive Medicine Terms and Conditions

5. Figure 4
Immunohistochemical detection of COX-2 in ovaries of OHHS rats ± meloxicam. (A) A representative ovarian section showing the immunolocalization of COX-2 in a control rat (×100). (B) A representative ovarian section from an OHSS rat (×100). (C) A representative ovarian section from an OHSS plus meloxicam-treated rat (×250). (D) A representative ovarian section from a control rat where the anti-COX-2 antisera was omitted (×100). (E) Densitometric analyses of COX-2 immunoreactivity in the rat ovaries. Superscript letters designate statistically significant differences (P≤.05). See text for abbreviations.
Fertility and Sterility  , DOI: ( /j.fertnstert )
Copyright © 2008 American Society for Reproductive Medicine Terms and Conditions