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Gene Discovery for Complex Traits: Lessons from Africa

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1 Gene Discovery for Complex Traits: Lessons from Africa
Jon M. McClellan, Thomas Lehner, Mary-Claire King  Cell  Volume 171, Issue 2, Pages (October 2017) DOI: /j.cell Copyright © 2017 Elsevier Inc. Terms and Conditions

2 Figure 1 Haplotype Heterozygosity of Human Populations as a Function of Distance from Addis Ababa, Ethiopia, East Africa Haplotypes were constructed from 650k common SNPs and microsatellites genotyped for 938 unrelated individuals from 51 populations on all continents (Li et al., 2008). Cell  , DOI: ( /j.cell ) Copyright © 2017 Elsevier Inc. Terms and Conditions

3 Figure 2 Human Migrations
Humans and chimpanzees diverged in Africa 5 to 6 million years ago. Migrations out of Africa by small groups of modern humans began less than 100,000 years ago. The genetics of African populations reveals variation that developed in between. Cell  , DOI: ( /j.cell ) Copyright © 2017 Elsevier Inc. Terms and Conditions

4 Figure 3 Proportions of Variants with Minor Allele Frequencies between 0.01 and 0.25 in Various Populations Allele frequencies are from whole genome data (1000 Genomes Project Consortium et al., 2015 and unpublished data). Cell  , DOI: ( /j.cell ) Copyright © 2017 Elsevier Inc. Terms and Conditions

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