1. Argentina
Arg-ADNI
Ezequiel Surace, PhD

2. Arg-ADNI Status 2012 Baseline Follow-up Follow-up Healthy Controls 15
Total Nº
NPS
Ass
MRI
CSF
Aβ-tau
PET FDG
PET
PiB
Follow-up
1 year
Follow-up 30 month
Follow-up 60 month
Healthy Controls 15 11 13 12 8
Early MCI 7 10 6
Late MCI 16 14 4
Dementia AD 9 2
TOTAL 56 40
(71%) 53
(95%) 50
(89%) 43

3. Reason for delay of the visit Too far from the center: 3
Arg-ADNI
Drop-out rates
2012
2017
2018
Patients Followed
(60 months)
Nº= 14 (so far…)
Patients Followed
(Baseline)
Nº= 56
Patients Followed
(1st year)
Nº= 50
Patients Followed
(30 months)
Nº= 43
Drop-out rate 10.7%
Nº= 6
Drop-out rate 14%
Nº= 7
Reason for delay of the visit
Drop-out: 3
Passed away: 4
Too far from the center: 3
Hospitalized: 4

4. 60-month visit (ongoing) (Only for PiB- at baseline)
Arg-ADNI
60-month visit (ongoing)
60-month visit
Baseline
Follow-up 60 month
NPS
Ass
Alz Costs Survey
MRI
CSF
PET PiB
(Only for PiB- at baseline)
PET-tau AV-1451
Healthy Controls 15 8 x
Early MCI 12
Late MCI 16 4
Dementia AD 13 2
TOTAL 56 14

5. has funded this study completely
Arg-ADNI
Limitations
Small cohort generates difficulties in data analysis
Baseline
Follow-up
Initially, our intention was to apply for grants to increase cohort number, but:
Available grants contemplate incorporation of preventive interventions. Also, these grants are not sufficient for “omics” analyses
From the participant’s standpoint: they manifest less enthusiasm to participate, especially of they are already symptomatic
We have not been able to convince other Latin American centers to participate in order to share efforts
has funded this study completely

6. Arg-ADNI Future directions
We will complete the 60-month visit (estimated 1 more year)
Baseline
Follow-up
Data analysis will take a further year
For now, we do not anticipate to extend the protocol further
Based on the limitations, it would be more feasible to apply to preclinical intervention-based grants
Arg-ADNI group will participate in FINGER meeting, AA LATAM Face to Face and Alzheimer Prevention Initiative during this meeting

7. Arg-ADNI What we have learned
ADNI served as a model of how other similar initiatives should be implemented and standarized in our institution
PiB-PET, Tau-PET, Spanish adaptation of neuropsychological tests, CSF biomarkers (QC program)
Administration of data from multiple sources into integrated databases
Consolidation of a multi-disciplinary group

8. IASDA
ARGENTINE INITIATIVE FOR THE STUDY OF DOWN SYNDROME AND ALZHEIMER’S
Established December 2017
3-year longitudinal study
CSF biomarkers
Yearly clinical / neuropsychological evaluation
Confirmatory cytogenetic study
DNA / Plasma
Structural MRI
PiB-PET /FDG-PET

9. IASDA
ARGENTINE INITIATIVE FOR THE STUDY OF DOWN SYNDROME AND ALZHEIMER’S
Established December 2017
Completed Baseline
Remaining 10
Recruit 5 more participants
Neuropsychological assessment
MRI
Participants recruited: 15
Women: 9
Median age : 41 (21-58)