1. TransDisciplinary Research in Traditional Medicine Rasayana Mode of Action

2. Health & Diseases Health Disease Biological System
a. Enhanced structural features
- Development
- Maintenance
- Regeneration
b. Enhanced function
c. Maintenance of structure and function
Disease
a. Infections
b. Functional disorders
c. Degenerative disorders

3. Contemporary Relevance
Current mainstream healthcare system offers diagnosis tools and only symptomatic treatment for chronic diseases
Lack of solutions for wellness and disease prevention
Very few disease limiting and/or modifying drugs/practices
Frequent side-effects
Long and expensive procedure for developing a drug from a lead molecule

4. Contemporary Relevance
Ayurveda can be useful for enhanced nervous system health
Promotes/enhances health
Possible preventive age related and life style disorders.
Disease limiting/modifying ability
Safe and easy way to improve or maintain nervous system health

5. Missing Links Clinical Lab
Lack of integrative documentation for efficacy of the treatment
inclusion objective assessment parameters
protocols for assessment and treatment
Lab
Relevant model systems for translational research
Understanding of mode of action of the FORMULATIONS at the cellular and molecular level

6. Rasayana Concept of Wellness
Bridging Shastra and Science
Concepts, Practice and Research
Rasayana Concept of Wellness
Rasayana tantra deals with anti-aging, strengthening,
promoting longevity, retentive intelligence and
curative measures of the diseases
Shrotoshodhana
Clearing of body channels
Agnivyapara
Optimization of metabolism
Poshana
Providing Nourishment

7. Pharmacological Understanding
Bridging Shastra and Science
Concepts, Practice and Research
AYURVEDA
Pharmacological Understanding
Ashwagandha
Withanis somnifera
Brahmi
Bacopa monnieri
Amla
Phylanthus emblica
Dadima
Punica granatum

8. Molecular and Cellular understanding
Bridging Shastra and Science
Concepts, Practice and Research
MODERN SCIENCE
Tools and Techniques
Molecular and Cellular understanding

9. Promotive and Preventive
Health & Diseases
Biological System
Health
Promotive and Preventive
Disease
Disease modifying/ Management

10. Working Strategy AYURVEDA MODERN SCIENCE Practice
Concepts
Practice
MODERN SCIENCE
Clinical Research
Mode of Action Research

11. Anaemia: A Metabolic Disorder Shrotoshodhana: Clear, Optimally Functional Body Channels
Venkatasubramanian et al., 2013

12. Amla Enhances Bioavailability of Iron
Anaemia: A Metabolic Disorder Agni Vyapara-Enhanced Metabolism
Amla Enhances Bioavailability of Iron
Amla
Phylanthus emblica
Venkatasubramanian et al., 2014

13. Piper longum Formulations
Pippali is hot potency herb, so is piperine
If taken as milk decoction it works better with less of side effects.
Example: Antibiotic side effects
TDU Data base, credits Dr. Venugopalan

14. Prevention and Promotion
Dadima (Pomegranate) Enhances Life span and Healthspan
Lifespan analysis
Healthspan
Climbing assay
Fruit fly
Drosophila melanogaster
Balasubramani et al., 2014

15. Brahmi Improves Short Term Memory of Caenorhabditis elegans
Prevention and Promotion
Brahmi Improves Short Term Memory of Caenorhabditis elegans
Brahmi
Bacopa monnieri
Rasa: Tikta, Kashaya
Guna: Laghu, Pichhila
Veerya: Sita
Vipaka: Madhura

16. Clearing up the plaques Shrotishodhana or Agnivyapara?
Treatment with Ashwagandha reduces plaque load in brains of Transgenic Mice with Alzheimer’s Disease
Sehgal et al, 2015

17. Integrated clinical management Parkinson’s Disease
Disease Treatment & Management
Integrated clinical management Parkinson’s Disease
Total UPDRS Score

18. Disease Model: Mode of Action
Parkinson’s Disease Treatment protocol
CONTROL
CEP neurons
L1 Larvae treated for 20h with 5mM MPP+
Degenerated CEP neurons
Brahmi Mitigates MPP+ Iodide Induced Neurodegeneration in
Parkinson’s Disease Model of Caenorhabditis elegans

19. Summary Modern BioMedicine Ayurveda Functional Science
Structural Sciences
Systems Perspective

20. Thank you