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Overexpression of transforming growth factor–β1 correlates with increased synthesis of nitric oxide synthase in varicose veins  Theresa Jacob, PhD, Anil.

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Presentation on theme: "Overexpression of transforming growth factor–β1 correlates with increased synthesis of nitric oxide synthase in varicose veins  Theresa Jacob, PhD, Anil."— Presentation transcript:

1 Overexpression of transforming growth factor–β1 correlates with increased synthesis of nitric oxide synthase in varicose veins  Theresa Jacob, PhD, Anil Hingorani, MD, Enrico Ascher, MD  Journal of Vascular Surgery  Volume 41, Issue 3, Pages (March 2005) DOI: /j.jvs Copyright © 2005 The Society for Vascular Surgery Terms and Conditions

2 Fig 1 Representative photomicrographs of immunohistochemical analysis in vein wall (all at original magnification ×400 unless indicated otherwise). Formalin-fixed paraffin-embedded tissues were processed for immunolocalization of proteins as described under Methods. Brown staining (peroxidase) (arrows) indicates immunopositivity. Photomicrographs depict the staining pattern. A, Negative control (nc). Nontortuous varicose vein (vv). B, CD68+ cells in tortuous varicose vein. C, Transforming growth factor-β1 (TGF-β1) in control vein (nv) tissue. D, TGF-β1 in non-tortuous varicose vein tissue. E, Inducible nitric oxide synthase (iNOS) expression in control vein. F, iNOS expression in tortuous varicose vein tissue (original magnification ×200). Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2005 The Society for Vascular Surgery Terms and Conditions

3 Fig 2 Western blot analysis for expression of transforming growth factor-β1 (TGF-β1) and inducible (iNOS) and endothelial (eNOS) nitric oxide synthases. Comparison of the normal vein (NV), tortuous varicose vein (VV-t), and nontortuous varicose vein (VV-nt) segments. GAPDH, glyceraldehyde phosphate dehydrogenase. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2005 The Society for Vascular Surgery Terms and Conditions

4 Fig 3 Immunohistochemical analysis for expression of transforming growth factor-β1 (TGF-β1) and inducible nitric oxide synthases (iNOS). Comparison of the normal vein (NV), tortuous varicose vein (VV-t) and non-tortuous varicose vein (VV-nt) segments. All values are expressed as mean ± SEM. Values for tortuous varicose vein and normal vein segments were significantly different (P < .01). Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2005 The Society for Vascular Surgery Terms and Conditions

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