1. Production of Neoepitopes by Dynamic Structural Changes on BP180/Type XVII Collagen 
Takashi Hashimoto, Norito Ishii, Daisuke Tsuruta 
Journal of Investigative Dermatology 
Volume 137, Issue 12, Pages (December 2017)
DOI: /j.jid
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2. Figure 1
The schematic representation of human BP180 with sites for enzyme cleavage and neoepitopes for linear IgA bullous dermatosis (LABD), as well as possible influences of both N- and C-terminal regions on exposure of LABD neoepitopes. The red bar indicates the region containing LABD neoepitopes. Green arrows indicate the enzyme digestion sites within the NC16a and NC4 domains. Recombinant proteins with C-terminal deletion up to the NC10 domain also reacted with IgA antibodies in LABD sera.
Journal of Investigative Dermatology  , DOI: ( /j.jid )
Copyright © 2017 The Authors Terms and Conditions